Advanced Ultrasound in Diagnosis and Therapy ›› 2024, Vol. 8 ›› Issue (4): 231-241.doi: 10.37015/AUDT.2024.240053

• Review Articles • Previous Articles     Next Articles

Advancements in BaTiO3-Based Ultrasound‐Triggered Piezoelectric Catalysis for Tumor Therapy

Shama Shitia, Xie Xinxina, Wu Ruiqia, He Pinga, Li Xiaodab, Chen Qingfengc, Liang Xiaolonga,*()   

  1. aDepartment of Ultrasound, Peking University Third Hospital, Beijing, China
    bPeking University Health Science Center, Beijing, China
    cInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore
  • Received:2024-10-07 Accepted:2024-10-30 Online:2024-12-30 Published:2024-11-12
  • Contact: Liang Xiaolong, E-mail:xiaolong_liang@bjmu.edu.cn

Abstract:

Barium titanate (BaTiO3), as an emerging inorganic piezoelectric material with excellent piezoelectric catalytic effects, has showing advantages in tumor therapy. To achieve ultrasound-regulated tumor treatment using BaTiO3, researchers have developed strategies including utilizing BaTiO3 combined with ultrasound for tumor therapy, enhancing reactive oxygen species (ROS) generation through chemical modification of BaTiO3, and employing combined therapy with other treatment methods. These strategies provide new insights and approaches for non-invasive and precision treatment of tumors. In this review, we first explain the principle of piezoelectric effect based on BaTiO3. Subsequently, we introduce the application of BaTiO3 as a piezoelectric material in tumor therapy and its combined therapy with other treatment modalities in tumor treatment. Finally, we summarize the current status and limitations of BaTiO3 in ultrasound‐triggered piezoelectric therapy for tumors and propose future prospects.

Key words: Barium titanate; Ultrasound; Piezoelectric catalysis; Tumor therapy