State-of-the-Art and Development Trend of Interventional Ultrasound in China

doi:10.37015/AUDT.2023.230049

Abstract

Abstract:

Interventional ultrasound (IUS) is an important branch of modern minimally invasive medicine that has been widely applied in clinical practice due to its unique techniques and advantages. As a relatively emerging field, IUS has progressed towards standardization, precision, intelligence, and cutting-edge directions alone with more than 40 years of development, which is becoming increasingly important techniques in clinical medicine. This article will briefly review the development and advancement of IUS for diagnosis and treatment in China in the era of precision medicine from the aspects of artificial intelligence, virtual navigation, molecular imaging, and nanotechnology.

Key words: Interventional ultrasound; Precision medicine; Molecular imaging; Artificial intelligence; Nanotechnology

Yang Qi, MD, Dengsheng Sun, MD, Linyao Wang, MD, Jie Yu, MD, Ping Liang, MD. State-of-the-Art and Development Trend of Interventional Ultrasound in China. Advanced Ultrasound in Diagnosis and Therapy, 2023, 7(4): 313-320.

References 67

[1]	Chen MH, Liang P, Wang JR. Chinese interventional ultrasound. 1st ed.ed. Beijing: People’s Medical Publishing House 2017: 1.
[2]	Grant EG, Richardson JD, Smirniotopoulos JG, Jacobs NM. Fine-needle biopsy directed by real-time sonography: technique and accuracy. Am J Roentgenol 1983; 141:29-32. pmid: 6602522
[3]	Goldberg BB, Pollack HM. Ultrasonic aspiration transducer. Radiology 1972; 102:187-189. pmid: 5008144
[4]	Holm HH, Kristensen JK, Rasmussen SN, Northeved A, Barlebo H. Ultrasound as a guide in percutaneous puncture technique. Ultrasonics 1972; 10:83-86. pmid: 5017591
[5]	Saitoh M, Watanabe H, Ohe H, Tanaka S, Itakura Y, Date S. Ultrasonic real-time guidance for percutaneous puncture. J Clin Ultrasound 1979; 7:269-272. pmid: 112114
[6]	Sugiura N, Takara K, Ohto M. Percutaneous intratumoral injection of ethanol under ultrasound imaging for treatment of small hepatocellular carcinoma. Acta Hepatol Jpn 1983; 24:920-923. doi: 10.2957/kanzo.24.920
[7]	Goldberg S N, Gazelle GS, Solbiati L, Rittman WJ, Mueller PR. Radiofrequency tissue ablation: increased lesion diameter with a perfusion electrode. Acad Radiol 1996; 3:636-644. pmid: 8796727
[8]	Wang L, Xu J, Yu J, Liang P. Review of clinical tumor ablation advance in Asia. Int J Hyperthermia 2021; 38:1639-1649. doi: 10.1080/02656736.2021.1983037
[9]	Wang Z, Liu M, Zhang DZ, Wu SS, Hong ZX, He GB, et al. Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC. Hepatology 2022; 76:66-77.
[10]	Zheng L, Dou JP, Han ZY, Liu FY, Yu J, Cheng ZG, et al. Microwave ablation for papillary thyroid microcarcinoma with and without US-detected capsule invasion: A multicenter prospective cohort study. Radiology 2023; 307:e220661. doi: 10.1148/radiol.220661
[11]	Huang J, Zhang J, Wang Y, Kong W, Xue W, Liu DM, et al. Comparing zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for clinical T1a renal tumor: A randomized clinical trial. J Urol 2016; 195:1677-1683. doi: 10.1016/j.juro.2015.12.115 pmid: 26905020
[12]	Wang H, Xue W, Yan W, Yin L, Dong B, He B, et al. Extended focal ablation of localized prostate cancer with high-frequency irreversible electroporation: A nonrandomized controlled trial. JAMA Surg 2022; 157:693-700. doi: 10.1001/jamasurg.2022.2230 pmid: 35793110
[13]	Gou Q, Wu L, Cui W, Mo Z, Zeng D, Gan L, et al. Stent placement combined with intraluminal radiofrequency ablation and hepatic arterial infusion chemotherapy for advanced biliary tract cancers with biliary obstruction: a multicentre, retrospective, controlled study. Eur Radiol 2021; 31:5851-5862. doi: 10.1007/s00330-021-07716-0 pmid: 33585991
[14]	Zhang YQ, Wu YL, Feng Y, Zhou YX. A clinical study on microwave ablation in combination with chemotherapy in treating peripheral IIIB-IV non-small cell lung cancer. Cancer Biother Radiopharm 2022; 37:141-146.
[15]	Wu F, Wang ZB, Cao YD, Chen JB, Zou JZ, Zhu H. A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer 2003; 89:2227-2233. doi: 10.1038/sj.bjc.6601411
[16]	Yang Q, Li H, Chen BH, He GZ, Wu XP, Wang LX, et al. Ultrasound-guided percutaneous microwave ablation for 755 benign breast lesions: a prospective multicenter study. Eur Radiol 2020; 30:5029-5038. doi: 10.1007/s00330-020-06868-9 pmid: 32356159
[17]	Ren C, Liang P, Yu XL, Cheng ZG, Han ZY, Yu J. Percutaneous microwave ablation of adrenal tumours under ultrasound guidance in 33 patients with 35 tumours: A single-centre experience. Int J Hyperthermia 2016; 32:517-523. doi: 10.3109/02656736.2016.1164905
[18]	Dong B. Ultrasonically guided percutaneous fine needle biopsy in the diagnosis of pancreatic tumors. Zhonghua Nei Ke Za Zhi 1982; 21:716-718,775-776.
[19]	Xu Z, Chen M, Wu M. Diagnosis value of B mode ultrasound for primary liver cancer. Chinese Journal of Internal Digestion 1982; 2:223-226.
[20]	Chen M, Liang P. Guidelines for the application of interventional ultrasound. Beijing: People's Medical Publishing House 2014.
[21]	Dahiya DS, Al-Haddad M, Chandan S, Gangwani MK, Azizi M, Mohan B, et al. Artificial intelligence in endoscopic ultrasound for pancreatic cancer: Where are we now and what does the future entail? J Clin Med 2022; 11:7476. doi: 10.3390/jcm11247476
[22]	Wang K, Lu X, Zhou H, Gao YY, Zheng J, Tong MH, et al. Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study. Gut 2019; 68:729-741. doi: 10.1136/gutjnl-2018-316204 pmid: 29730602
[23]	Liu F, Liu D, Wang K, Xie XH, Su LY, Kuang M, et al. Deep learning Radiomics based on contrast-enhanced ultrasound might optimize curative treatments for very-early or early-stage hepatocellular carcinoma patients. Liver Cancer 2020; 9:397-413. doi: 10.1159/000505694 pmid: 32999867
[24]	Xu HL, Gong TT, Liu FH, Chen HY, Xiao Q, Hou Y, et al. Artificial intelligence performance in image-based ovarian cancer identification: A systematic review and meta-analysis. EClinicalMedicine 2022; 53:101662. doi: 10.1016/j.eclinm.2022.101662
[25]	Sun R, Limkin EJ, Vakalopoulou M, Dercle L, Champiat S, Han SR, et al. A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study. Lancet Oncol 2018; 19:1180-1191. doi: S1470-2045(18)30413-3 pmid: 30120041
[26]	Wang X, Xie T, Luo J, Zhou Z, Yu X, Guo X. Radiomics predicts the prognosis of patients with locally advanced breast cancer by reflecting the heterogeneity of tumor cells and the tumor microenvironment. Breast Cancer Res 2022; 24:20. doi: 10.1186/s13058-022-01516-0 pmid: 35292076
[27]	Huang W, Jiang Y, Xiong W, Sun Z, Chen C, Yuan Q, et al. Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer. Nat Commun 2022; 13:5095. doi: 10.1038/s41467-022-32816-w pmid: 36042205
[28]	Su GH, Xiao Y, Jiang L, Zheng R, Wang H, Chen Y, et al. Radiomics features for assessing tumor-infiltrating lymphocytes correlate with molecular traits of triple-negative breast cancer. J Transl Med 2022; 20:471. doi: 10.1186/s12967-022-03688-x
[29]	Kang W, Qiu X, Luo Y, Luo J, Liu Y, Xi J, et al. Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis. J Transl Med 2023; 21:598. doi: 10.1186/s12967-023-04437-4
[30]	Hu HT, Wang W, Chen LD, Ruan S, Chen S, Li X, et al. Artificial intelligence assists identifying malignant versus benign liver lesions using contrast-enhanced ultrasound. J Gastroenterol Hepatol 2021; 36:2875-2883. doi: 10.1111/jgh.v36.10
[31]	Guo HL, Lu XZ, Hu HT, Ruan S, Zheng X, Xie X, et al. Contrast-enhanced ultrasound-based nomogram: A potential predictor of individually postoperative early recurrence for patients with combined hepatocellular-cholangiocarcinoma. J Ultrasound Med 2022; 41:1925-1938. doi: 10.1002/jum.v41.8
[32]	Chen F, Liu J, Wan P, Liao H, Kong W. Immunohistochemical index prediction of breast tumor based on multi-dimension features in contrast-enhanced ultrasound. Med Biol Eng Comput 2020; 58:1285-1295. doi: 10.1007/s11517-020-02164-2 pmid: 32232794
[33]	Huang J, Xie X, Wu H, Zhang X, Zheng Y, Xie X, et al. Development and validation of a combined nomogram model based on deep learning contrast-enhanced ultrasound and clinical factors to predict preoperative aggressiveness in pancreatic neuroendocrine neoplasms. Eur Radiol 2022; 32:7965-7975. doi: 10.1007/s00330-022-08703-9 pmid: 35389050
[34]	Long Y, Xu E, Zeng Q, Ju J, Huang Q, Liang P, et al. Intra-procedural real-time ultrasound fusion imaging improves the therapeutic effect and safety of liver tumor ablation in difficult cases. J Cancer Res 2020; 10:2174-2184.
[35]	Xu E, Li K, Long Y, Luo L, Zeng Q, Tan L, et al. Intra-procedural CT/MR-ultrasound fusion imaging helps to improve outcomes of thermal ablation for hepatocellular carcinoma: Results in 502 nodules. Ultraschall Med 2021; 42:e9-e19.
[36]	Gu JH, Zhao QY, He C, Ye Z, Xu M, Jiang T. Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization. Int J Hyperthermia 2021; 38:1092-1098. doi: 10.1080/02656736.2021.1943545
[37]	Huang Q, Zeng Q, Long Y, Tan L, Zheng R, Xu E, et al. Fusion imaging techniques and contrast-enhanced ultrasound for thermal ablation of hepatocellular carcinoma-A prospective randomized controlled trial. Int J Hyperthermia 2019; 36:1207-1215.
[38]	Wang XL, Li K, Su ZZ, Huang ZP, Wang P, Zheng RQ. Assessment of radiofrequency ablation margin by MRI-MRI image fusion in hepatocellular carcinoma. World J Gastroenterol 2015; 21:5345-5351. doi: 10.3748/wjg.v21.i17.5345
[39]	Ding WZ, Liu S, Liu F, Cheng Z, Yu X, Han Z, et al. Are all local tumour progressions of HCC related to thermal ablation? A study of the causes and classification of local tumour progression. Eur Radiol 2022; 32:8518-8526. doi: 10.1007/s00330-022-08913-1
[40]	Hu Y, Qi E, Liu F, Lu Y, Tan S, Sun Y, et al. The application of a three-dimensional visualized seed planning and navigation system in 125I seed implantation for pancreatic cancer. Onco Targets Ther 2018; 11:619-627. doi: 10.2147/OTT
[41]	An C, Li X, Zhang M, Yang J, Cheng Z, Yu X, et al. 3D visualization ablation planning system assisted microwave ablation for hepatocellular carcinoma (Diameter >3): A precise clinical application. BMC Cancer 2020;20:44.
[42]	Li X, An C, Liu F, Cheng Z, Han Z, Yu X, et al. The value of 3D visualization operative planning system in ultrasound-guided percutaneous microwave ablation for large hepatic hemangiomas: A clinical comparative study. BMC Cancer 2019; 19:550. doi: 10.1186/s12885-019-5682-5 pmid: 31174503
[43]	Boctor EM, Fischer G, Choti MA, Fichtinger G, Taylor RH. A Dual-armed robotic system for intraoperative ultrasound guided hepatic ablative therapy: A prospective study. IEEE International Conference on Robotics and Automation 2004: 2517-2522.
[44]	Liu P, Qin J, Duan B, Wang Q, Tan X, Zhao B, et al. Overlapping radiofrequency ablation planning and robot-assisted needle insertion for large liver tumors. Int J Med Robot 2019; 15:e1952.
[45]	Li D, Cheng Z, Chen G, Liu F, Wu W, Yu J, Gu Y, et al. A multimodality imaging-compatible insertion robot with a respiratory motion calibration module designed for ablation of liver tumors: A preclinical study. Int J Hyperthermia 2018; 34:1194-1201. doi: 10.1080/02656736.2018.1456680
[46]	Lan M, Zhu L, Wang Y, Shen D, Fang K, Liu Y, et al. Multifunctional nanobubbles carrying indocyanine green and paclitaxel for molecular imaging and the treatment of prostate cancer. J Nanobiotechnology 2020; 18:121. doi: 10.1186/s12951-020-00650-1
[47]	Li M, Luo H, Zhang W, He K, Chen Y, Liu J, et al. Phase-shift, targeted nanoparticles for ultrasound molecular imaging by low intensity focused ultrasound irradiation. Int J Nanomedicine 2018; 13:3907-3920. doi: 10.2147/IJN
[48]	Wang Y, Lan M, Shen D, Fang K, Zhu L, Liu Y, et al. Targeted nanobubbles carrying indocyanine green for ultrasound, photoacoustic and fluorescence imaging of prostate cancer. Int J Nanomedicine 2020; 15:4289-4309. doi: 10.2147/IJN.S243548
[49]	Zhu L, Wang L, Liu Y, Xu D, Fang K, Guo Y. CAIX aptamer-functionalized targeted nanobubbles for ultrasound molecular imaging of various tumors. Int J Nanomedicine 2018; 13:6481-6495. doi: 10.2147/IJN
[50]	Feng Y, Hao Y, Wang Y, Song W, Zhang S, Ni D, et al. Ultrasound molecular imaging of bladder cancer via extradomain B Fibronectin-targeted biosynthetic GVs. Int J Nanomedicine 2023; 18:4871-4884. doi: 10.2147/IJN.S412422
[51]	Hao Y, Luo J, Wang Y, Li Z, Wang X, Yan F. Ultrasound molecular imaging of p32 protein translocation for evaluation of tumor metastasis. Biomaterials 2023; 293:121974. doi: 10.1016/j.biomaterials.2022.121974
[52]	Zhong J, Su M, Jiang Y, Huang L, Chen Y, Huang Z, et al. VEGFR2 targeted microbubble-based ultrasound molecular imaging improving the diagnostic sensitivity of microinvasive cervical cancer. Nanobiotechnology 2023; 21:220.
[53]	Hao Y, Li Z, Luo J, Li L, Yan F. Ultrasound molecular imaging of epithelial mesenchymal transition for evaluating tumor metastatic potential via targeted biosynthetic gas vesicles. Small 2023; 19:e2207940.
[54]	Xu L, Du J, Wan C, Zhang Y, Xie S, Li H, et al. Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly (lactic-co-glycolic acid) nanocapsules: A novel dual-targeted ultrasound contrast agent. Int J Nanomedicine 2018; 13:1791-1807. doi: 10.2147/IJN
[55]	Luo W, Wen G, Yang L, Tang J, Wang J, Wang J, et al. Dual-targeted and pH-sensitive doxorubicin prodrug-microbubble complex with ultrasound for tumor treatment. Theranostics 2017; 7:452-465. doi: 10.7150/thno.16677 pmid: 28255342
[56]	Liu Y, Wang Z, Liu Y, Zhu G, Jacobson O, Fu X, et al. Suppressing nanoparticle-mononuclear phagocyte system interactions of two-dimensional gold nanorings for improved tumor accumulation and photothermal ablation of tumors. ACS Nano 2017; 11:10539-10548. doi: 10.1021/acsnano.7b05908 pmid: 28953351
[57]	Hu Z, Wang S, Dai Z, Zhang H, Zheng X. A novel theranostic nano-platform (PB@FePt-HA-g-PEG) for tumor chemodynamic-photothermal co-therapy and triple-modal imaging (MR/CT/PI) diagnosis. J Mater Chem B 2020; 8:5351-5360. doi: 10.1039/d0tb00708k pmid: 32458958
[58]	Yang Z, Zhu Y, Dong Z, Li W, Yang N, Wang X, et al. Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses. Nat Commun 2021; 12:4299. doi: 10.1038/s41467-021-24604-9 pmid: 34262038
[59]	Xiong J, Wu M, Chen J, Liu Y, Chen Y, Fan G, et al. Cancer-erythrocyte hybrid membrane-camouflaged magnetic nanoparticles with enhanced photothermal-immunotherapy for ovarian cancer. ACS Nano 2021; 15:19756-19770. doi: 10.1021/acsnano.1c07180 pmid: 34860006
[60]	Long D, Liu T, Tan L, Shi H, Liang P, Tang S, et al. Multisynergistic platform for tumor therapy by mild microwave irradiation-activated chemotherapy and enhanced ablation. ACS Nano 2016; 10:9516-9528. doi: 10.1021/acsnano.6b04749 pmid: 27689440
[61]	Hou L, Tian C, Yan Y, Zhang L, Zhang H, Zhang Z. Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity. ACS Nano 2020; 14:3927-3940. doi: 10.1021/acsnano.9b06111
[62]	Pan J, Hu P, Guo Y, Hao J, Ni D, Xu Y, et al. Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments. ACS Nano 2020; 14:1033-1044. doi: 10.1021/acsnano.9b08550 pmid: 31935064
[63]	Feng L, Xie R, Wang C, Gai SM He F, Yang D, et al. Magnetic targeting, tumor microenvironment-responsive intelligent nanocatalysts for enhanced tumor ablation. ACS Nano 2018; 12: 11000-11012. doi: 10.1021/acsnano.8b05042 pmid: 30339353
[64]	Yu X, Gao D, Gao L, Lai J, Zhang C, Zhao Y, et al. Inhibiting metastasis and preventing tumor relapse by triggering host immunity with tumor-targeted photodynamic therapy using photosensitizer-loaded functional nanographenes. ACS Nano 2017; 11:10147-10158. doi: 10.1021/acsnano.7b04736 pmid: 28901740
[65]	Zhu A, Miao K, Deng Y, Ke H, He H, Yang T, et al. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano 2015; 9:7874-7885. doi: 10.1021/acsnano.5b02843 pmid: 26181349
[66]	Hou Q, Zhang K, Chen S, Chen J, Zhang Y, Gong N, et al. Physical & chemical microwave ablation (MWA) enabled by nonionic MWA nanosensitizers repress incomplete MWA-arised liver tumor recurrence. ACS Nano 2022; 16:5704-5718. doi: 10.1021/acsnano.1c10714
[67]	Han X, Wang R, Xu J, Chen Q, Liang C, Chen J, et al. In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence. Biomaterials 2019; 224:119490. doi: 10.1016/j.biomaterials.2019.119490