Advanced Ultrasound in Diagnosis and Therapy ›› 2024, Vol. 8 ›› Issue (4): 231-241.doi: 10.37015/AUDT.2024.240053
• Review Articles • Previous Articles Next Articles
Shama Shitia, Xie Xinxina, Wu Ruiqia, He Pinga, Li Xiaodab, Chen Qingfengc, Liang Xiaolonga,*()
Received:
2024-10-07
Accepted:
2024-10-30
Online:
2024-12-30
Published:
2024-11-12
Contact:
Liang Xiaolong,
E-mail:xiaolong_liang@bjmu.edu.cn
Shama Shiti, Xie Xinxin, Wu Ruiqi, He Ping, Li Xiaoda, Chen Qingfeng, Liang Xiaolong. Advancements in BaTiO3-Based Ultrasound‐Triggered Piezoelectric Catalysis for Tumor Therapy. Advanced Ultrasound in Diagnosis and Therapy, 2024, 8(4): 231-241.
Figure 2
(A) Schematic representation of tumor therapy initiated by the piezoelectric effect; (B) Timeline of O2 evolution from P-BTO nanoparticles; (C) Fluorescence microscopy images of DCFH-DA in 4T1 cells following various treatments; (D) Changes in tumor volume in mice bearing 4T1 tumors; (E) Relative levels of HIF-α following different treatments. (Reprinted with permission from[22]. Copyright 2021, American Chemical Society.)"
Figure 3
(A) Schematic illustration of efficient tumor chemotherapy utilizing US-triggered piezoelectric catalysis combined with a nanomedicine approach; (B) Fluorescence intensity of SOSG triggered by ultrasound across various samples; (C) NO release profiles of different experimental groups upon ultrasound activation; (D) Release behavior of CPT from various samples under ultrasound stimulation; (E) Quantitative analysis of calcein-AM/PI fluorescence images from Panc02 tumor cells subjected to different treatments; (F) Tumor growth curves for mice following various treatment regimens. (Reprinted with permission from [27]. Copyright 2023, American Chemical Society.)"
Figure 4
(A) Schematic of the piezoelectric effect to enhance tumor NO gas therapy; (B) US-triggered O2 generation at different power intensities; (C) US-triggered 1O2 generation at different power intensities; (D) US-triggered NO generation at different power intensities; (E) Quantitative analysis of HIF-1α protein levels in 4T1 cells via Western blotting following different treatments; (F) Changes in tumor volume among different groups of mice with 4T1 tumors. (Reprinted with permission from [28]. Copyright 2023, American Chemical Society.)"
Figure 5
(A) Schematic illustration of BTO nanoparticles coated with membranes that overexpress M-αPD-L1; (B) Assessment of ROS generation capabilities across various groups; (C) O2 production levels in different experimental groups; (D) Fluorescence microscopy images showing the release of CRT, HMGB1, and HSP70 following various treatments; (E) Changes in tumor volume in mice bearing B16F10 tumors after different treatment regimens; (F) Photographic representation of B16F10 tumors post-treatment. (Reprinted with permission from [29]. Copyright 2023, John Wiley and Sons.)"
Figure 6
(A) Schematic illustration of the synthesis of Met@BF nanohybrids and their enhanced immunochemotherapy effects for melanoma; (B) Release behavior of Fe ions from Met@BF nanohybrids at various pH levels; (C) H2O2 concentrations in different samples following ultrasound irradiation; (D) Confocal fluorescence images depicting CRT surface exposure and HMGB1 secretion in B16F10 cells after various treatments; (E) Tumor growth curves for C57BL/6 mice with B16F10 tumors subjected to different treatment protocols. (Reprinted with permission from [30]. Copyright 2024, American Chemical Society)"
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