Advanced Ultrasound in Diagnosis and Therapy ›› 2022, Vol. 6 ›› Issue (4): 147-152.doi: 10.37015/AUDT.2022.200034

• Review Articles • Previous Articles     Next Articles

Research Progress in Ultrasonic Regulation of Cholinergic Anti-inflammatory Pathway

Wuqi Zhou, MDa,b,c,1, Yishu Song, MDa,b,c,1, Rui Wang, MDa,b,c, Qiaofeng Jin, MDa,b,c, Mingxing Xie, PhDa,b,c, Li Zhang, PhDa,b,c,*()   

  1. a Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    b Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
    c Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
  • Received:2022-09-01 Revised:2022-09-22 Accepted:2022-10-06 Online:2022-12-30 Published:2022-10-25
  • Contact: Li Zhang, PhD,
  • About author:First author contact:1 Wuqi Zhou and Yishu Song contributed equally to this study.


The cholinergic anti-inflammatory pathway is a neuro-immune regulatory pathway that mediates anti-inflammatory effects based on the vagus nerve, acetylcholine and α7 nicotinic acetylcholine receptors. In recent years, the effect of nerve stimulation by ultrasound has attracted much attention and has been widely studied. Ultrasound can stimulate the vagus nerve or spleen nerve and activate the cholinergic anti-inflammatory pathway, exerting anti-inflammatory and organ protection effects, which is expected to provide a new treatment for many inflammatory diseases. The purpose of this review is to introduce the composition, mechanisms and regulation methods of cholinergic anti-inflammatory pathway, and discuss its therapeutic implications.

Key words: Ultrasound; Vagus nerve; The cholinergic anti-inflammatory pathway; α7 nicotinic acetylcholine receptors