Advanced Ultrasound in Diagnosis and Therapy ›› 2022, Vol. 6 ›› Issue (3): 122-124.doi: 10.37015/AUDT.2021.210027

• Case Reports • Previous Articles     Next Articles

Contrast-enhanced Ultrasound Features of Lymphoepithelioma-Like Cholangiocarcinoma with Multiple Metastases: A Case Report

Guiwu Chen, MSa, Wenqin Liu, MSa, Zhizhong He, PhDa, Xiaomin Liao, MSb, Yuhuan Xie, PhDa,*()   

  1. a Department of Ultrasound, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, China
    b Department of Pathology, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, China
  • Received:2021-09-06 Revised:2021-09-27 Online:2022-09-30 Published:2022-08-08
  • Contact: Yuhuan Xie, PhD,


Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is an intrahepatic cholangiocarcinoma with a prominent lymphoid infiltrate. According to previous reports, most LEL-CCs are a single lesion with a notably better prognosis compared to typical liver cancers. However, most literature reported pathological features and lacked imaging features, especially that of ultrasound. We report on a 74-year-old female with LEL-CC presented with headache and malaise for six months. We performed superficial ultrasonography, abdominal ultrasonography, hepatic contrast-enhanced ultrasound, positron emission tomography-computed tomography, and ultrasound-guided biopsy. We definitively diagnosed LEL-CC with multiple metastases in the liver, skeleton, and lymph nodes.

Key words: Ultrasonography; Contrast-enhanced imaging; Cholangiocarcinoma; Liver; Metastasis