Advanced Ultrasound in Diagnosis and Therapy ›› 2018, Vol. 2 ›› Issue (2): 128-132.doi: 10.37015/AUDT.2018.180811

• Original Research • Previous Articles     Next Articles

Ultrasound Characteristics of Kimura Disease: Retrospective Analysis of 30 cases

Bingyan Liu, MD*(), Shaoqing Fu, MD, Dongni Luo, MD, Shengxin Fu, MD, Donglin Wang, MD, Wei Liao, MD   

  1. Department of ultrasonography, Hainan General Hospital, Haikou, Hainan, China
  • Received:2018-07-01 Online:2018-08-18 Published:2018-08-19
  • Contact: Bingyan Liu, MD,


Objective: To demonstrate the characteristics of the lesion in Kimura disease on ultrasound imaging and compare with clinical features in patients with pathologically-approved Kimura disease.
Methods: A total of 30 patients (29 men and 1 woman; a mean age of 35.4 years) with Kimura disease confirmed by surgery and pathology were enrolled in the study. Ultrasonographic findings were analyzed retrospectively and compared with clinical features and laboratory examinations to better understand the relationship among them.
Results: All patients presented with painless, progressively enlarged soft tissue masses in head and neck, axillary, inguinal regions or limb extremities. Laboratory results showed elevation of eosinophils in both peripheral blood and serum IgE in 12 of 30 cases. Ultrasound findings of the lesions in Kimura disease were divided into three types: Type I: characterized by simple lymph node enlargement; Type II: characterized by flake-like thickening of the lesion without mass effect, and enlargement of nearby lymph nodes; Type III: a tumor-like lesion associate with enlargement of nearby lymph nodes.
Conclusion: The Kimura disease has specific ultrasonographic characteristics of lymph node and adjacent structures. When combined with patient’s clinical information and laboratory tests, ultrasound examination can provide useful information for making clinical diagnosis and management.

Key words: Kimura disease; eosinophilic lymphogranuloma; ultrasound