Case Reports

An Epstein-Barr Virus Positive Lymphoepithelioma-Like Cholangiocarcinoma in A Young Woman with Chronic Hepatitis B Treated through Microwave Ablation: A Case Report and Literature Review

  • Lanxia Zhang, MM ,
  • Qingjing Zeng, MD ,
  • Guanghui Guo, MM ,
  • Xuqi He, MM ,
  • Kai Li, MD
Expand
  • aDepartment of Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China. e-mail: likai@mail.sysu.edu.cn

Received date: 2022-12-22

  Revised date: 2023-03-09

  Accepted date: 2023-05-09

  Online published: 2023-10-23

Abstract

Lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare subtype of carcinoma that is poorly reported. We report a case of LELCC in a 28-year-old female with chronic hepatitis B. She underwent secondary microwave ablation for residual tumor following the failure of radiofrequency ablation (RFA). Image fusion technology was used to accurately diagnose that the second lesion represented residual tumor. This case is the second successful application of microwave ablation in the treatment of LELCC. We first reviewed the ultrasonographic features of LELCC. We report this case to improve our understanding of this disease and provide evidence for its clinical treatment.

Cite this article

Lanxia Zhang, MM , Qingjing Zeng, MD , Guanghui Guo, MM , Xuqi He, MM , Kai Li, MD . An Epstein-Barr Virus Positive Lymphoepithelioma-Like Cholangiocarcinoma in A Young Woman with Chronic Hepatitis B Treated through Microwave Ablation: A Case Report and Literature Review[J]. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY, 2023 , 7(4) : 405 -408 . DOI: 10.37015/AUDT.2023.220049

References

[1] Huang YH, Zhang CZ, Huang QS, Yeong J, Wang F, Yang X, et al. Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma. J Hepatol 2021; 74:838-849.
[2] Liao TC, Liu CA, Chiu NC, Yeh YC, Chiou YY. Lymphoepithelioma-like cholangiocarcinoma: A mimic of hepatocellular carcinoma on imaging features. World J Gastroenterol 2015; 21:4089-4095.
[3] Labgaa I, Stueck A, Ward SC. Lymphoepithelioma-like carcinoma in liver. Am J Pathol 2017; 187:1438-1444.
[4] Chiang NJ, Hou YC, Tan KT, Tsai HW, Lin YJ, Yeh YC, et al. The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma. Hepatol Int 2022; 16:1137-1149.
[5] Nogami A, Saito S, Hasegawa H, Yoneda M, Harada K, Fujikawa H. Lymphoepithelioma-like cholangiocarcinoma with Epstein-Barr virus infection treated by radiofrequency ablation. Clin J Gastroenterol 2021; 14:638-644.
[6] Li X, Ji H, Zhang D, Jin M, Guo X, Gao P, et al. Lymphoepithelioma-like cholangiocarcinoma with hepatitis C virus infection treated by microwave ablation: A literature review and case report. Cancer Manag Res 2022; 14:2155-2160.
[7] Vortmeyer AO, Kingma DW, Fenton RG, Curti BD, Jaffe ES, Duray PH. Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein-Barr virus. Am J Clin Pathol 1998; 109:90-95.
[8] Yang Q, Cai Q, Wen H, Mao Y, Ban X, Rong D, et al. The CT and MRI features of primary intrahepatic lymphoepithelioma-like cholangiocarcinoma. AJR Am J Roentgenol 2021; 216:393-402.
[9] Wang XL, Li K, Su ZZ, Huang ZP, Wang P, Zheng RQ. Assessment of radiofrequency ablation margin by MRI-MRI image fusion in hepatocellular carcinoma. World J Gastroenterol 2015; 21:5345-5351.
[10] Li C, Zhu A. Application of image fusion in diagnosis and treatment of liver cancer. Applied Sciences 2020; 10:1171.
[11] Facciorusso A, Abd El Aziz MA, Tartaglia N, Ramai D, Mohan BP, Cotsoglou C, et al. Microwave ablation versus radiofrequency ablation for treatment of hepatocellular carcinoma: a meta-analysis of randomized controlled trials. Cancers (Basel) 2020; 12:3796.
[12] Zhang M, Ma H, Zhang J, He L, Ye X, Li X. Comparison of microwave ablation and hepatic resection for hepatocellular carcinoma: a meta-analysis. Onco Targets Ther 2017; 10:4829-4839.
[13] Li FY, Li JG, Wu SS, Ye HL, He XQ, Zeng QJ, et al. An optimal ablative margin of small single hepatocellular carcinoma treated with image-guided percutaneous thermal ablation and local recurrence prediction base on the ablative margin: a multicenter study. J Hepatocell Carcinoma 2021; 8:1375-1388.
[14] Chen TC, Ng KF, Kuo T. Intrahepatic cholangiocarcinoma with lymphoepithelioma-like component. Mod Pathol 2001; 14:527-532.
[15] Jeng YM, Chen CL, Hsu HC. Lymphoepithelioma-like cholangiocarcinoma: An Epstein-Barr virus-associated tumor. Am J Surg Pathol 2001; 25:516-520.
[16] Ling W, Lu C, Huang H, Qiu T, Lu Q, Huang C, et al. Ultrasonographic findings of intrahepatic lymphoepithelioma-like cholangiocarcinoma associated with Epstein-Barr virus: Two cases report. Medicine 2019; 98:e14206.
[17] Zhang X, Wang N, Wei W, Li Y. Epstein-Barr virus infection-associated cholangiocarcinoma: A report of one case and the review of literature. Virol J 2022; 19:133.
[18] Chen G, Liu WQ, He ZZ, Liao XM, Xie YH. Contrast-enhanced ultrasound features of lymphoepithelioma-like cholangiocarcinoma with multiple metastases: A case report. AUDT 2022; 6:122-124.
Outlines

/