Time-intensity Curve Analysis of Hepatocellular Carcinoma using Two Contrast-enhanced Ultrasound Methods: Contrast Pulse Sequencing and Contrast Harmonic Imaging

doi:10.37015/AUDT.2020.200007

Abstract

Abstract:

Objectives: To compare the features of the time-intensity curve (TIC) of hepatocellular carcinoma (HCC) by two different contrast-enhanced ultrasound (CEUS) methods: Contrast Pulse Sequencing (CPS) and Contrast Harmonic Imaging (CHI).
Methods: This prospective study included 22 HCC lesions. The CPS and CHI (Cadence? technique by Siemens) were performed in random order for each lesion, and the microbubbles were completely cleared between the two methods. The imaging by each method was recorded for 10 minutes. The CEUS video clips were analyzed off-line and the quantitative parameters of time intensity curve were obtained: the peak intensity (PI), time to peak (TTP), washout time (WT), relative value (RV) of intensity and AUC before WT and after WT, and the time of RV ≥15 dB lasted (RLT).
Results: Compared with CPS, CHI showed an earlier WT (64.0 ± 17.1 s vs 33.1 ± 7.0 s) of HCC lesions, a lower RV of intensity (36.8 ± 9.4 vs 10.3 ± 5.1) and AUC (1377.2 ± 205.7 vs 227.2 ± 56.7) before WT, but higher RV of intensity (17.8 ± 4.6 vs 32.2 ± 8.6) and AUC (1 124.1 ± 276.4 vs 2 664.1 ± 456.8) after WT, and longer RLT (121.4 ± 49.8 s vs > 150 s).
Conclusion: For long later phase observation after washout, CHI is better than CPS, but the observation of rapid perfusion before washout is not comparable to CPS. A combined use of these two methods is recommended based on our research.

Key words: Contrast enhanced ultrasound; Contrast pulse sequence; Contrast harmonic imaging; Time-intensity curve; Hepatocellular carcinoma

Mengna He, MD, PhD, Lei Xu, MD, Tian’an Jiang, MD, PhD. Time-intensity Curve Analysis of Hepatocellular Carcinoma using Two Contrast-enhanced Ultrasound Methods: Contrast Pulse Sequencing and Contrast Harmonic Imaging. Advanced Ultrasound in Diagnosis and Therapy, 2020, 4(3): 217-222.

[1]	Zehui Fu, MD, Chuxue Sun, MD, Haixia Zhou, MD, Xiaowen Lv, MD, Siqi Wang, MD, Hui Chen, MD. Multimodal Vascular Ultrasound Findings in A Young Female with Internal Carotid Artery Dissection [J]. Advanced Ultrasound in Diagnosis and Therapy, 2023, 7(1): 28-31.
[2]	Ting Tian, MM, Youjun Wang, BM, Xiaojing Tian, BM. Conventional Ultrasound Combined with Contrast-enhanced Ultrasound for Diagnosis of the Congenital Incomplete Transverse Vaginal Septum: A Case Report [J]. Advanced Ultrasound in Diagnosis and Therapy, 2023, 7(1): 47-49.
[3]	Esika Savsani, Mohamed Tantawi, MD, Corinne E. Wessner, MBA, RDMS, RVT, Philip Lee, MD, Andrej Lyshchik, MD, PhD, Kevin Anton, MD, PhD, Colette M. Shaw, MD, Ji-Bin Liu, MD, John R. Eisenbrey, PhD. Contrast-enhanced Ultrasound Assessment of Treatment Response in a Patient with Multifocal Hepatocellular Carcinoma Treated with Transarterial Chemo and Radioembolization [J]. Advanced Ultrasound in Diagnosis and Therapy, 2021, 5(3): 254-257.
[4]	Yan Zhou, Jianmin Ding, Fengmei Wang, Zhengyi Qin, Yandong Wang, Hongyu Zhou, Xiang Jing. The Effects of Liver Function Damage after Thermal Ablation on the Prognosis of HCC Patients and Its Prediction [J]. Advanced Ultrasound in Diagnosis and Therapy, 2021, 5(2): 80-86.
[5]	Mengna He, MD, PHD, Lu Zhu, MD, Tianan Jiang, MD, PHD. Findings of Fat Containing Hepatocellular Carcinoma on Contrast-enhanced Ultrasound with Sonazoid: A Case Report [J]. Advanced Ultrasound in Diagnosis and Therapy, 2021, 5(2): 98-101.
[6]	Li Ma, MD, Wenzhao Liang, MD, Yupeng Zhu, MD, Yingqiao Zhu, MD, Dezhi Zhang, MD. Differences in CEUS and CE-MRI Appearance of HCC: A Case Report [J]. Advanced Ultrasound in Diagnosis and Therapy, 2019, 3(4): 197-199.
[7]	Sriharsha Gummadi, MD, John Eisenbrey, PhD, Jingzhi Li, MD, Zhaojun Li, MD, Flemming Forsberg, PhD, Andrej Lyshchik, MD, Ji-Bin Liu, MD. Advances in Modern Clinical Ultrasound [J]. Advanced Ultrasound in Diagnosis and Therapy, 2018, 2(2): 51-63.
[8]	Meng Li, MD, Zhiyan Li, MD, Yuejuan Gao, MD. Hepatic Angiomyolipoma: A Case Report [J]. Advanced Ultrasound in Diagnosis and Therapy, 2018, 2(2): 164-166.
[9]	Meng Li, MD, Zhiyan Li, MD, Yuejuan Gao, MD, Jiangke Tian, MD, Min Chen, MD, Jinghui Dong, MD. Safety and Efficacy of Percutaneous Radiofrequency Ablation Combined with Percutaneous Ethanol Injection for Hepatocellular Carcinoma in High-risk Locations [J]. Advanced Ultrasound in Diagnosis and Therapy, 2018, 2(1): 1-7.
[10]	Jianmin Ding, MD, Yan Zhou, MD, Yandong Wang, MD, Hongyu Zhou, MD, Xiang Jing, MD. Clinical Value of Contrast-enhanced Ultrasound in Differential Diagnosis of Early Hepatocellular Carcinoma and Dysplastic Nodules [J]. Advanced Ultrasound in Diagnosis and Therapy, 2017, 1(1): 10-14.
[11]	Xianghong Luo, MD, Qian Zhang, MD, Qing Yan, MD, Jufang Wang, MD, Qingqing Dong, MD, Zhaojun Li, MD. Diagnosis with Echocardiography for Rare Cases of Anomalous Left Main Coronary Artery: Two Case Reports and Important Lessons Learned [J]. Advanced Ultrasound in Diagnosis and Therapy, 2017, 1(1): 15-18.

Time-intensity Curve Analysis of Hepatocellular Carcinoma using Two Contrast-enhanced Ultrasound Methods: Contrast Pulse Sequencing and Contrast Harmonic Imaging

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 11

Metrics

Comments