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Advances in the Application of New Ultrasound Technology for the Diagnosis and Treatment of Lymphoma
Received date: 2024-06-04
Revised date: 2024-07-07
Accepted date: 2024-07-15
Online published: 2025-02-08
Lymphoma is a common hematological malignancy with markedly increasing incidence. Its pathological types are complex and heterogeneous, and there are significant differences in treatment options and efficacy. Therefore, early and precise diagnosis, assessment of efficacy, and judgment of prognosis are key clinical problems. Ultrasound (US) has important clinical value in the diagnosis and treatment of lymphoma. This article reviews the progress made with new US technologies in improving the accuracy of diagnosis and staging of lymphoma, predicting the course of lymphoma, monitoring the progression of lesions during treatment, and assisting clinics in formulating accurate and effective treatment plans. In addition, we review the biological basis of US prediction of lymphoma and provide an outlook for future research directions.
Key words： Ultrasound technology; Lymphoma; Diagnosis; Treatment
Bao Rui , Chen Lu , Luo Yukun , Zhang Mingbo . Advances in the Application of New Ultrasound Technology for the Diagnosis and Treatment of Lymphoma[J]. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY, 2025 , 9(1) : 32 -40 . DOI: 10.37015/AUDT.2025.240025
| [1] | Bispo JAB, Pinheiro PS, Kobetz EK. Epidemiology and etiology of leukemia and lymphoma. Cold Spring Harb Perspect Med 2020;10:a034819. |
| [2] | Smith A, Crouch S, Lax S, Li J, Painter D, Howell D, et al. Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network. Br J Cancer 2015;112:1575-1584. |
| [3] | Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: lymphoid neoplasms. Leukemia 2022;36:1720-1748. |
| [4] | Neelapu SS, Adkins S, Ansell SM, Brody J, Cairo MS, Friedberg JW, et al. Society for immunotherapy of cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lymphoma. J Immunother Cancer 2020;8:e001235. |
| [5] | Bia?ek EJ, Jakubowski W. Mistakes in ultrasound diagnosis of superficial lymph nodes. J Ultrason 2017;17:59-65. |
| [6] | Shah HJ, Keraliya AR, Jagannathan JP, Tirumani SH, Lele VR, DiPiro PJ. Diffuse large B-cell lymphoma in the era of precision oncology: how imaging is helpful. Korean J Radiol 2017;18:54-70. |
| [7] | Ahuja A, Ying M. Sonography of neck lymph nodes. Part II: abnormal lymph nodes. Clin Radiol 2003;58:359-366. |
| [8] | Kwok HM, Ng FH, Chau CM, Lam SY, Ma JKF. Multimodality imaging of extra-nodal lymphoma in the head and neck. Clin Radiol 2022;77:e549-e559. |
| [9] | Li N, Li M, Zhang Q, Wei J, Liu B. First-time diagnosis and ultrasound features of extranodal lymphoma in children. J Oncol 2022;2022:4229112. |
| [10] | Zhang R, Zhang M, Deng R, Li Y, Guo C. Lymphoma-related intussusception in children: Diagnostic challenges and clinical characteristics. Eur J Pediatr 2024;183:219-227. |
| [11] | Qiu L, Luo Y, Peng YL. Value of ultrasound examination in differential diagnosis of pancreatic lymphoma and pancreatic cancer. World J Gastroenterol 2008;14:6738-6742. |
| [12] | Li YA, Zhang Y, Wang W, Wei C, Zhao DQ, Zhang W. A comprehensive model for diagnosis of primary breast lymphoma differentiated from breast cancer and prognosis evaluation of surgical treatment. Front Oncol 2022;12:858696. |
| [13] | Chen Y, Zhou JH, Fan HX, Luo Y, Peng YL, Ma BY. Ultrasound diagnosis of breast lymphoma and the identification of breast infiltrating ductal carcinoma. J Ultrasound Med 2020;39:1203-1211. |
| [14] | Zhang XM, Wei BX, Nong L, Zhang H, Gao Y, Ou JP. The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma. Front Endocrinol 2022;13:1054584. |
| [15] | Gu LS, Cui NY, Wang Y, Che SN, Zou SM, He W, et al. Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. J Thorac Dis 2017;9:4774-4784. |
| [16] | Dragoni F, Cartoni C, Pescarmona E, Chiarotti F, Puopolo M, Orsi E, et al. The role of high resolution pulsed and color Doppler ultrasound in the differential diagnosis of benign and malignant lymphadenopathy: results of multivariate analysis. Cancer 1999;85:2485-2490. |
| [17] | Na DG, Lim HK, Byun HS, Kim HD, Ko YH, Baek JH. Differential diagnosis of cervical lymphadenopathy: usefulness of color Doppler sonography. AJR Am J Roentgenol 1997;168:1311-1316. |
| [18] | Bialek EJ, Jakubowski W, Szczepanik AB, Maryniak RK, Prochorec-Sobieszek M, Bilski R, et al. Vascular patterns in superficial lymphomatous lymph nodes: a detailed sonographic analysis. J Ultrasound 2007;10:128-134. |
| [19] | Cocco G, Boccatonda A, D'Ardes D, Galletti S, Schiavone C. Mantle cell lymphoma: from ultrasound examination to histological diagnosis. J Ultrasound 2018;21:339-342. |
| [20] | Ahuja AT, Ying M, Ho SY, Antonio G, Lee YP, King AD, et al. Ultrasound of malignant cervical lymph nodes. Cancer Imaging 2008;8:48-56. |
| [21] | Gkali CA, Chalazonitis AN, Feida E, Giannos A, Sotiropoulou M, Dimitrakakis C, et al. Primary non-Hodgkin lymphoma of the breast: ultrasonography, elastography, digital mammography, contrast-enhanced digital mammography, and pathology findings. Ultrasound Quarterly 2015;31:279-282. |
| [22] | Kachramanoglou C, Rafailidis V, Philippidou M, Bertolotto M, Huang DY, Deganello A, et al. Multiparametric sonography of hematologic malignancies of the testis: grayscale, color Doppler, and contrast-enhanced ultrasound and strain elastographic appearances with histologic correlation. J Ultrasound Med 2017;36:409-420. |
| [23] | Sousaris N, Barr RG. Sonoelastography of breast lymphoma. Ultrasound Quarterly 2016;32:208-211. |
| [24] | Tong J, Lin T, Wen B, Chen P, Wang Y, Yu Y, et al. The value of multimodal ultrasound in diagnosis of cervical lymphadenopathy: can real-time elastography help identify benign and malignant lymph nodes? Front Oncol 2023;13:1073614. |
| [25] | Tan R, Xiao Y, He Q. Ultrasound elastography: its potential role in assessment of cervical lymphadenopathy. Acad Radiol 2010;17:849-855. |
| [26] | Schr?der C, Lock G, Schmidt C, L?ning T, Dieckmann KP. Real-time elastography and contrast-enhanced ultrasonography in the evaluation of testicular masses: a comparative prospective study. Ultrasound Med Biol 2016;42:1807-1815. |
| [27] | Liu N, Chen Y, Wang Y, Huang W, Zhan L, Du Z, et al. A combination of ultrasound and contrast-enhanced ultrasound improves diagnostic accuracy for the differentiation of cervical tuberculous lymphadenitis from primary lymphoma. Clin Hemorheol Microcirc 2023;85:261-275. |
| [28] | Zhang YQ, Wang XY, Huang Y. The findings on the CEUS of diffuse large B cell lymphoma in abdomen: a case report and literature review. Front Oncol 2023;13:1093196. |
| [29] | Trenker C, Kunsch S, Michl P, Wissniowski TT, Goerg K, Goerg C. Contrast-enhanced ultrasound (CEUS) in hepatic lymphoma: retrospective evaluation in 38 cases. Ultraschall Med 2014;35:142-148. |
| [30] | Cui NY, Gong XT, Tian YT, Wang Y, Zhang R, Liu MJ, et al. Contrast-enhanced ultrasound imaging for intestinal lymphoma. World J Gastroenterol 2021;27:5438-5447. |
| [31] | Trenker C, Neesse A, G?rg C. Sonographic patterns of renal lymphoma in B-mode imaging and in contrast-enhanced ultrasound (CEUS)--a retrospective evaluation. Eur J Radiol 2015;84:807-810. |
| [32] | Yang L, Tao Y, Weixin Z, Meiling B, Jing H. Contrast-enhanced and microvascular ultrasound imaging features of testicular lymphoma: report of five cases and review literature. BMC Urol 2022;22:6. |
| [33] | Yang LL, Zhao HN, He YS, Zhu XL, Yue C, Luo Y, et al. Contrast-enhanced ultrasound in the differential diagnosis of primary thyroid lymphoma and nodular Hashimoto's thyroiditis in a background of heterogeneous parenchyma. Front Oncol 2021;10:597975. |
| [34] | Yang Z, Cai J, Wang Y, Shu L, Liu W, Wang Z. Comparison of Doppler imaging and microvascular imaging in cervical lymph node blood flow analysis. Curr Med Imaging 2024;20:e15734056306197. |
| [35] | Bayramoglu Z, Caliskan E, Karakas Z, Karaman S, Tugcu D, Somer A, et al. Diagnostic performances of superb microvascular imaging, shear wave elastography and shape index in pediatric lymph nodes categorization: A comparative study. Br J Radiol 2018;91:20180129. |
| [36] | Sim JK, Lee JY, Hong HS. Differentiation between malignant and benign lymph nodes: role of superb microvascular imaging in the evaluation of cervical lymph nodes. J Ultrasound Med 2019;38:3025-3036. |
| [37] | He MN, Lv K, Jiang YX, Jiang TA. Application of superb microvascular imaging in focal liver lesions. World J Gastroenterol 2017;23:7765-7775. |
| [38] | Spiesecke P, Schmidt J, Peters R, Fischer T, Hamm B, Lerchbaumer MH. Assessment of quantitative microflow vascular index in testicular cancer. Eur J Radiol 2024;176:111513. |
| [39] | Ishikawa M, Ota Y, Nagai M, Kusaka G, Tanaka Y, Naritaka H. Ultrasonography monitoring with superb microvascular imaging technique in brain tumor surgery. World Neurosurg 2017;97:749.e11-749.e20. |
| [40] | Ishikawa M, Masamoto K, Hachiya R, Kagami H, Inaba M, Naritaka H, et al. Neurosurgical intraoperative ultrasonography using contrast enhanced superb microvascular imaging -vessel density and appearance time of the contrast agent. Br J Neurosurg 2023;37:485-494. |
| [41] | Elhamdoust E, Motamedfar A, Gharibvand MM, Jazayeri SN. Investigation of the value of ultrasound-guided core needle biopsy from pathologic lymph nodes to the diagnosis of lymphoma. J Family Med Prim Care 2020;9:2801-2805. |
| [42] | Cuenca-Jimenez T, Chia Z, Desai A, Moody A, Ramesar K, Grace R, et al. The diagnostic performance of ultrasound-guided core biopsy in the diagnosis of head and neck lymphoma: results in 226 patients. Int J Oral Maxillofac Surg 2021;50:431-436. |
| [43] | Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM. Ultrasound-guided biopsy of suspected salivary gland lymphoma in Sjogren's syndrome. Arthritis Care Res 2021;73:849-855. |
| [44] | Han CQ, Lin R, Xu MY, Liu J, Ding Z. Primary mucosa-associated lymphoid tissue lymphoma of the entire esophagus diagnosed by endoscopic ultrasound-guided fine needle aspiration. Endoscopy 2022;54:E694-E695. |
| [45] | Chen CN, Huang TC, Yu SC, Ko JY, Yang TL. Incorporation of ultrasound-guided core biopsy with flow cytometry to assist the diagnosis of cervical lymphoma. Eur Arch Oto-Rhino-Laryn 2023;280:1437-1446. |
| [46] | Orsini-Arman A, Surjan R, Venco F, Ardengh JC. Primary pancreatic lymphoma: endosonography-guided tissue acquisition diagnosis. Cureus 2023;15:e34936. |
| [47] | Ariza-Prota MA, Bango álvarez A, Pérez L, Pando-Sandoval A, Fuentes N, Casan P. From cytology to histology: diagnosis of a relapsed mediastinal lymphoma by endobronchial ultrasound transbronchial histological needle. Respirol Case Rep 2015;3:68-71. |
| [48] | Labarca G, Sierra-Ruiz M, Kheir F, Folch E, Majid A, Mehta HJ, et al. Diagnostic accuracy of endobronchial ultrasound transbronchial needle aspiration in lymphoma. A systematic review and meta-analysis. Ann Am Thorac Soc 2019;16:1432-1439. |
| [49] | Creemers K, van der Heiden O, Los J, van Esser J, Newhall D, Djamin RS, et al. Endoscopic ultrasound fine needle aspiration in the diagnosis of lymphoma. J Oncol 2011;2011:785425. |
| [50] | Kennedy MP, Jimenez CA, Bruzzi JF, Mhatre AD, Lei X, Giles FJ, et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax 2008;63:360-365. |
| [51] | Li J, Han J, Wang Y, Mo Y, Li J, Xiang J, et al. Core needle biopsy targeting the viable area of deep-sited dominant lesion verified by color Doppler and/or contrast-enhanced ultrasound contribute to the actionable diagnosis of the patients suspicious of lymphoma. Front Oncol 2020;10:500153. |
| [52] | Taiji R, Marugami N, Marugami A, Itoh T, Shimizu S, Nakano R, et al. Multimodality imaging of primary hepatic lymphoma: a case report and a literature review. Diagnostics (Basel) 2024;14:306. |
| [53] | Luo J, Huang F, Zhou P, Chen J, Sun Y, Xu F, et al. Is ultrasound combined with computed tomography useful for distinguishing between primary thyroid lymphoma and Hashimoto's thyroiditis? Endokrynol Pol 2019;70:463-468. |
| [54] | Peng C, Yi D, Zhou Y, Yao J, Chen B, Yang C, et al. Differential diagnosis of non-diffuse primary thyroid lymphoma and papillary thyroid carcinoma by ultrasound combined with computed tomography. BMC Cancer 2022;22:938. |
| [55] | Khan S, Naim S, Bilwani R, Salem A, Gorlin D, Muhammad A, et al. Radiogenomics and its role in lymphoma. Curr Hematol Malig Rep 2020;15:211-224. |
| [56] | Lyu S, Zhang M, Yang L, Zhang B, Gao L, Yang L, et al. Application of machine-learning based on radiomics features in differential diagnosis of superficial lymphadenopathy. Curr Med Imaging 2024. |
| [57] | Liu Y, Chen J, Zhang C, Li Q, Zhou H, Zeng Y, et al. Ultrasound-based radiomics can classify the etiology of cervical lymphadenopathy: a multi-center retrospective study. Front Oncol 2022;12:856605. |
| [58] | Shi J, Jiang J, Chang W, Chen M, Zhang Q. Multi-class discrimination of lymphadenopathy by using dual-modal ultrasound radiomics with elastography and B-mode ultrasound. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019;36:957-963. |
| [59] | Zhu YY, Meng ZL, Fan X, Duan Y, Jia YY, Dong TT, et al. Deep learning radiomics of dual-modality ultrasound images for hierarchical diagnosis of unexplained cervical lymphadenopathy. BMC Med 2022;20:269. |
| [60] | Lu W, Chen W, Zhou Y, Yuan Y, Shu H, Deng H, et al. A model to predict the prognosis of diffuse large B-cell lymphoma based on ultrasound images. Sci Rep 2023;13:3346. |
| [61] | Kariya A, Tachibana T, Hiramatsu Y, Wani Y, Matsumoto JY, Furukawa C, et al. Primary thyroid lymphoma: clinical factors predicting the possibility of diffuse large B-cell lymphoma. Ear Nose Throat J 2023;1455613231218130. |
| [62] | Li P, Zhang H. Ultrasonography in the diagnosis and monitoring of therapy for primary thyroid lymphoma. Ultrasound Q 2019;35:246-252. |
| [63] | Trenker C, Kümpel J, Michel C, Safai Zadeh E, Dietrich CF, Timmesfeld N, et al. Assessment of early therapy response of non-Hodgkin's and Hodgkin's lymphoma using B-mode ultrasound and dynamic contrast-enhanced ultrasound. J Ultrasound Med 2022;41:2033-2040. |
| [64] | Xin L, Yan ZM, Zhang XJ, Zang YC, Ding ZY, Xue HW, et al. Parameters for contrast-enhanced ultrasound (CEUS) of enlarged superficial lymph nodes for the evaluation of therapeutic response in lymphoma: a preliminary study. Med Sci Monitor 2017;23:5430-5438. |
| [65] | Peil-Grun A, Trenker C, G?rg K, Neesse A, Haasenritter J, G?rg C. Diagnostic accuracy and interobserver agreement of contrast-enhanced ultrasound in the evaluation of residual lesions after treatment for malignant lymphoma and testicular cancer: A retrospective pilot study in 52 patients. Leuk Lymphoma 2018;59:2622-2627. |
| [66] | Kossev P, Livolsi V. Lymphoid lesions of the thyroid: review in light of the revised European-American lymphoma classification and upcoming World Health Organization classification. Thyroid 1999;9:1273-1280. |
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