Does Covid-19 Cause An Increase in Spleen Dimensions? Ultrasonography Study in People with Recent History of COVID-19 Infection and Healthy Participants

Syed Muhammad Yousaf Farooq, PhD; Syed Amir Gilani, PhD; Rabia Ejaz, BS; Sheeza Fatima, BS; Sarosh Imran, BS; Aleeza Naseer, BS

doi:10.37015/AUDT.2023.230056

ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY >

2024 , Vol. 8 >Issue 3: 130 - 134

DOI: https://doi.org/10.37015/AUDT.2023.230056

Original Research

Does Covid-19 Cause An Increase in Spleen Dimensions? Ultrasonography Study in People with Recent History of COVID-19 Infection and Healthy Participants

Syed Muhammad Yousaf Farooq, PhD ,
Syed Amir Gilani, PhD ,
Rabia Ejaz, BS ,
Sheeza Fatima, BS ,
Sarosh Imran, BS ,
Aleeza Naseer, BS

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^aRadiography and Imaging Technology, Green International University, Lahore, Pakistan
^bUniversity Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan

Radiography and Imaging Technology, Green International University, Lahore, Pakistan e-mail: Yousafgelani@gmail.com

Received date: 2023-11-28

Revised date: 2024-01-25

Accepted date: 2024-03-20

Online published: 2024-10-16

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Abstract

Objective: To determine whether COVID-19 causes an increase in spleen dimensions in individuals with a recent history of COVID-19 infection.

Methods: This case-control study was conducted at the Radiology Department of the University of Lahore Teaching Hospital and Sehat Medical Complex, both in Lahore. The study sample comprised 384 individuals, selected using a convenience sampling technique. Participants included individuals of all age groups and both genders; however, those under 18 were excluded due to the potential for incomplete spleen maturation. Other exclusion criteria included a history of splenectomy, the presence of traumatic or non-traumatic splenic lesions, or any other splenic abnormalities. Data collection commenced after obtaining approval from the Research Ethics Committee at the University of Lahore. The Siemens Sonovista c3000 Grey Scale Ultrasound Machine was used, and the data were analyzed using SPSS version 24.

Results: In a study involving 384 participants, the mean age was 35.7 ± 6.14, ranging from 22 to 50 years. Of these, 296 (71.1%) were female, and 88 (22.9%) were male. Echogenicity varied, with 29 participants (7.6%) exhibiting heterogeneous echogenicity and 355 (92.4%) showing homogeneous echogenicity. Spleen margins were irregular in 67 participants (17.4%) and smooth in 317 participants (82.6%). Regarding the history of Covid-19, 188 participants (49%) tested negative, while 196 participants (51%) tested positive.

Conclusion: Patients with a history of COVID-19 exhibited a significant increase in spleen length, volume, and thickness.

Key words： COVID-19; Spleen; Spleen dimensions; SARS-CoV-2; Pandemics

Cite this article

Syed Muhammad Yousaf Farooq, PhD , Syed Amir Gilani, PhD , Rabia Ejaz, BS , Sheeza Fatima, BS , Sarosh Imran, BS , Aleeza Naseer, BS . Does Covid-19 Cause An Increase in Spleen Dimensions? Ultrasonography Study in People with Recent History of COVID-19 Infection and Healthy Participants[J]. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY, 2024 , 8(3) : 130 -134 . DOI: 10.37015/AUDT.2023.230056

References

[1]	Álvarez Méndez A, Matía Almudévar P, Álvarez Hernández S. SARS-CoV2 bilateral pneumonia: chest X-ray evolution. Med Intensiva 2020;46:420-421.
[2]	Hakim MS. SARS‐CoV‐2, Covid‐19, and the debunking of conspiracy theories. Reviews in medical virology 2021;31:e2222.
[3]	Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet 2020; 395:497-506.
[4]	Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet 2020;395:507-513.
[5]	Haigh K, Syrimi ZJ, Irvine S, Blanchard TJ, Pervaiz MS, Toth AG, et al. Hyperinflammation with COVID-19: The key to patient deterioration? Clinical infection in practice 2020;7:100033.
[6]	Eljilany I, Elzouki A-N. D-dimer, fibrinogen, and IL-6 in COVID-19 patients with suspected venous thromboembolism: a narrative review. Vascular health and risk management 2020:455-462.
[7]	Landecho M, Yuste J, Gándara E, Sunsundegui P, Quiroga J, Alcaide A, et al. COVID‐19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? Journal of internal medicine 2021;289:116-120.
[8]	Feng Z, Diao B, Wang R, Wang G, Wang C, Tan Y, et al. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes. MedRxiv 2020:2020.03. 27.20045427.
[9]	Xu X, Chang X, Pan H, Su H, Huang B, Yang M, et al. Pathological changes of the spleen in ten patients with coronavirus disease 2019 (COVID-19) by postmortem needle autopsy. Zhonghua bing li xue za zhi 2020;49:576-582.
[10]	De Michele M, Kahan J, Berto I, Schiavo OG, Iacobucci M, Toni D, et al. Cerebrovascular complications of COVID-19 and COVID-19 vaccination. Circ Res 2022;130:1187-1203.
[11]	Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, et al. A new coronavirus associated with human respiratory disease in China. Nature 2020;579:265-269.
[12]	Xu X, Chang XN, Pan HX, Su H, Huang B, Yang M, et al. Pathological changes of the spleen in ten patients with coronavirus disease 2019 (COVID-19) by postmortem needle autopsy. Zhonghua bing li xue za zhi 2020;49:576-582.
[13]	Lamb PM, Lund A, Kanagasabay RR, Martin A, Webb JAW, Reznek RH. Spleen size: how well do linear ultrasound measurements correlate with threedimensional CT volume assessments? Br J Radiol 2002;75:573-577.
[14]	Elstein D, Hadas-Halpern I, Azuri Y, Abrahamov A, Bar-ziv Y, Zimran A. Accuracy of ultrasonography in assessing spleen and liver size in patients with Gaucher disease: comparison to computed tomographic measurements. J Ultrasound Med 1997;16:209-211.
[15]	Tahtabasi M, Hosbul T, Karaman E, Akin Y, Konukoglu O, Sahiner F. Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis. Clinical imaging 2021;79:104-109.
[16]	Haigh K, Syrimi ZJ, Irvine S, Blanchard TJ, Pervaiz MS, Toth AG, et al. Hyperinflammation with COVID-19: the key to patient deterioration? Clin Infect Pract 2020;7:100033.
[17]	Tabatabaei SMH, Talari H, Moghaddas F, Rajebi H. CT features and Short-term prognosis of COVID-19 pneumonia: a single-center study from Kashan. Iran Radiol Cardiothorac Imaging 2020;2: e200130.
[18]	SAMANCI C, ?AYLAN B, YE??LDAL M, CAMURCUOGLU E, USTABA?IO?LU FE. Evaluation of spleen volume in thoracic computed tomography in patients with COVID-19 pneumonia. Anatolian Current Medical Journal 2021;3:93-97.

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