ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY >

2022 , Vol. 6 >Issue 2: 39 - 47

DOI: https://doi.org/10.37015/AUDT.2022.220017

Review Article

Emerging Applications of Contrast-enhanced Ultrasound in Trauma

  • E. Tester, BS, MS Brenda ,
  • Liu, MD Ji-Bin ,
  • R. Eisenbrey, PhD John ,
  • Koenig, MD George
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  • a Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA
    b Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA
    c Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA

Received date: 2022-04-18

  Revised date: 2022-04-30

  Online published: 2022-06-26

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Abstract

The use of contrast-enhanced ultrasound (CEUS) has expanded over the past decade to include a variety of diagnostic and therapeutic applications. These include urgent clinical situations that require timely diagnosis and subsequent treatment. With the introduction of microbubble ultrasound contrast agents (UCAs), CEUS provides increased sensitivity and specificity over conventional ultrasound. Within the trauma setting, CEUS benefits include point of care imaging and an ability to monitor perfusion in real-time. Additionally, UCAs are non-nephrotoxic, and can be used when contrast enhanced CT is contraindicated. In this review, we discuss recent advancements of CEUS within trauma settings.

Key words： Contrast-enhanced ultrasound; Computed tomography; Abdominal trauma; Critical care; Bleeding

Cite this article

E. Tester, BS, MS Brenda , Liu, MD Ji-Bin , R. Eisenbrey, PhD John , Koenig, MD George . Emerging Applications of Contrast-enhanced Ultrasound in Trauma[J]. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY, 2022 , 6(2) : 39 -47 . DOI: 10.37015/AUDT.2022.220017

References

[1] Piscaglia F, Nolsøe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann Nielsen M, et al. The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 2012; 33:33-59.
[2] Cokkinos DD, Antypa E, Kalogeropoulos I, Tomais D, Ismailos E, Matsiras I, et al. Contrast-enhanced ultrasound performed under urgent conditions. Indications, review of the technique, clinical examples and limitations. Insights Imaging 2013; 4:185-198.
[3] Hsu JM, Joseph AP, Tarlinton LJ, Macken L, Blome S. The accuracy of focused assessment with sonography in trauma (FAST) in blunt trauma patients: experience of an an Australian major trauma service. Injury 2006; 38:71-75.
[4] Lyschik A. Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia PA, 2019.
[5] Miele V, Piccolo CL, Galluzzo M, Ianniello S, Sessa B, Trinci M. Contrast-enhanced ultrasound (CEUS) in blunt abdominal trauma. Br J Radiol 2016; 89: 20150823.
[6] Catalano O, Aiani L, Barozzi L, Bokor D, De Marchi A, Faletti C, et al. CEUS in abdominal trauma: multi-center study. Abdom Imaging 2009; 34:225-234.
[7] Valentino M, De Luca C, Galloni SS, Branchini M, Modolon C, Pavlica P, et al. Contrast-enhanced US evaluation in patients with blunt abdominal trauma. J Ultrasound 2010; 13:22-27
[8] Ahmed N, Vernick JJ. Management of liver trauma in adults. J Emerg Trauma Shock 2011; 4:114-119.
[9] Mieie V, Buffa V, Stasolla A, Regine G, Atzori M, Ialongo P, et al. Contrast enhanced ultrasound with second generation contrast agent in traumatic liver lesions. Radiol Med 2004; 108:82-91.
[10] Lv F, Tang J, Luo Y, Li Z, Meng X, Zhu Z, et al. Contrast-enhanced ultrasound imaging of active bleeding associated with hepatic and splenic trauma. Radiol Med 2011; 116:1076-1082.
[11] You JS, Chung YE, Lee HJ, Chung SP, Park I, Kim MJ, et al. Liver trauma diagnosis with contrast-enhanced ultrasound: interobserver variability between radiologist and emergency physician in an animal study. Am J Emerg Med 2012; 30:1229-1234.
[12] Richter C, Schwabe K, Grunert M, Friemert B. CEUS in gunshot wound of the liver-first experience in military mission. Ultrasound Med Biol 2019; 45: S64.
[13] Lv F, Tang J, Luo Y, Nie Y, Jiao Z, Li T, et al. Percutaneous treatment of blunt hepatic and splenic trauma under contrast-enhanced ultrasound guidance. Clinical Imaging 2012; 36:191-198.
[14] Chiavaroli R, Grima P, Tundo P. Characterization of nontraumatic focal splenic lesions using contrast-enhanced sonography. J Clin Ultrasound 2011; 39:310-315.
[15] Tagliati C, Argalia G, Graziani B, Salmistraro D, Giuseppetti GM, Giovagnoni A. Contrast-enhanced ultrasound in the evaluation of splenic injury healing time and grade. Radiol Med 2019; 124: 163.
[16] Tagliati C, Argalia G, Polonara G, Giovagnoni A, Giuseppetti GM. Contrast-enhanced ultrasound in delayed splenic vascular injury and active extravasation diagnosis. Radiol Med 2019; 124:170-175.
[17] Li W, Tang J, Lv F, Zhang H, Zhang S, An L. Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment. Radiol Med 2010; 115:1080-1086.
[18] Cagini L, Gravante S, Malaspina CM, Cesarano E, Giganti M, Rebonato A, et al. Contrast enhanced ultrasound (CEUS) in blunt abdominal trauma. Crit Ultrasound J 2013; 5: S9.
[19] Thorelius L. Emergency real-time contrast-enhanced ultrasonography for detection of solid organ injuries. Eur Radiol 2007; 17:F107-111.
[20] Pinto F, Valentino M, Romanini L, Basilico R, Miele V. The role of CEUS in the assessment of haemodynamically stable patients with blunt abdominal trauma. Radiol Med 2015; 120:3-11.
[21] Miele V, Piccolo CL, Sessa B, Trinci M, Galluzzo M. Comparison between MRI and CEUS in the follow-up of patients with blunt abdominal trauma managed conservatively. Radiol Med 2016; 121:27-37.
[22] Lin Q, Lv F, Luo Y, Song Q, Xu Q, Su Y, et al. Contrast-enhanced ultrasound for evaluation of renal trauma during acute hemorrhagic shock: a canine model. J Med Ultrason 2015; 42:199-205.
[23] Song Q, Tang J, Lv FQ, Zhang Y, Jiao ZY, Liu Q, et al. Evaluation of blunt pancreatic injury with contrast-enhanced ultrasonography in comparison with contrast-enhanced computed tomography. Exp Ther Med 2013; 5:1461-1465.
[24] Lv F, Tang J, Luo Y, Nie Y, Liang T, Jiao Z, et al. Emergency contrast-enhanced ultrasonography for pancreatic injuries in blunt abdominal trauma. Radiol Med 2014; 119:920-927.
[25] Lobianco R, Regine R, De Siero M, Catalano O, Caiazzo C, Ragozzino A. Contrast-enhanced sonography in blunt scrotal trauma. J Ultrasound 2011; 14:188-195.
[26] Sidhu Paul S. Diseases of the testis and epididymis. In: Allan P, Baxter, GM., Weston, MJ (ed) Clinical Ultrasound 2-Volume Set. 3rd ed. edn. Churchill Livingstone, London, pp 593-620.
[27] Catalano O, Lobianco R, Sandomenico F, Mattace Raso M, Siani A. Real-time, contrast-enhanced sonographic imaging in emergency radiology. Radiol Med 2004; 108:454-469.
[28] Moschouris H, Stamatiou K, Lampropoulou E, Kalikis D, Matsaidonis D. Imaging of the acute scrotum: is there a place for contrast-enhanced ultrasonography? Int Braz J Urol 2009; 35:692-705.
[29] Valentino M, Bertolotto M, Derchi L, Bertaccini A, Pavlica P, Martorana G, et al. Role of contrast enhanced ultrasound in acute scrotal diseases. Eur Radiol 2011; 21:1831-1840.
[30] Buckley JC, McAninch JW. Use of ultrasonography for the diagnosis of testicular injuries in blunt scrotal trauma. J Urol 2006; 175:175-178.
[31] Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA. Testicular seminoma and its mimics: from the radiologic pathology archives. Radiographics 2017; 37:1085-1098.
[32] Trinci M, Ferrari R, Ianniello S, Galluzzo M, Cirimele V, Miele V. Diagnostic value of contrast-enhanced ultrasound (CEUS) and comparison with color Doppler ultrasound and magnetic resonance in a case of scrotal trauma. J Ultrasound 2020; 23:189-194.
[33] Hildebrandt W, Schwarzbach H, Pardun A, Hannemann L, Bogs B, König AM, et al. Age- related differences in skeletal muscle microvascular response to exercise as detected by contrast-enhanced ultrasound (CEUS). PLoS One 2017; 12:e0172771.
[34] Amarteifio E, Wormsbecher S, Krix M, Demirel S, Braun S, Delorme S, et al. Dynamic contrast-enhanced ultrasound and transient arterial occlusion for quantification of arterial perfusion reserve in peripheral arterial disease. Eur J Radiol 2012; 81:3332-3338.
[35] Genovese EA, Callegari L, Combi F, Leonardi A, Angeretti MG, Benazzo F, et al. Contrast enhanced ultrasound with second generation contrast agent for the follow-up of lower extremity muscle-strain-repairing processes in professional athletes. Radiol Med 2007; 112:740-750.
[36] Hotfiel T, Heiss R, Swoboda B, Kellermann M, Gelse K, Grim C, et al. Contrast-enhanced ultrasound as a new investigative tool in diagnostic imaging of muscle injuries - a pilot study evaluating conventional ultrasound, CEUS, and findings in MRI. Clin J Sport Med 2018; 28:332-338.
[37] Kunz P, Mick P, Gross S, Schmidmaier G, Zeifang F, Weber MA, et al. Contrast-enhanced ultrasound (CEUS) as predictor for early retear and functional outcome after supraspinatus tendon repair. J Orthop Res 2020; 38:1150-1158.
[38] Geis S, Gehmert S, Lamby P, Zellner J, Pfeifer C, Prantl L, et al. Contrast enhanced ultrasound (CEUS) and time intensity curve (TIC) analysis in compartment syndrome: first results. Clin Hemorheol Microcirc 2012; 50:1-11.
[39] Dapunt U, Zhao Y, Schmidmaier G, Fischer C. Preoperative contrast-enhanced ultrasound (CEUS) of long bone nonunions reliably predicts microbiology of tissue culture samples but not of implant-sonication. Orthop Traumatol Surg Res 2021:102862.
[40] He W, Wang LS, Li HZ, Cheng LG, Zhang M, Wladyka CG. Intraoperative contrast-enhanced ultrasound in traumatic brain surgery. Clin Imaging 2013; 37:983-988
[41] Shin SS, Huisman TAGM, Hwang M. Ultrasound imaging for traumatic brain injury. J Ultrasound Med 2018; 37:1857-1867.
[42] Hwang M, Sridharan A, Darge K, Riggs B, Sehgal C, Flibotte J, et al. Novel quantitative contrast-enhanced ultrasound detection of hypoxic ischemic injury in neonates and infants: pilot study 1. J Ultrasound Med 2019; 38:2025-2038.
[43] Vinke EJ, Kortenbout AJ, Eyding J, Slump CH, van der Hoeven JG, de Korte CL, et al. Potential of contrast-enhanced ultrasound as a bedside monitoring technique in cerebral perfusion: a systematic review. Ultrasound Med Biol 2017; 43:2751-2757.
[44] Meairs S, Kern R. Intracranial perfusion imaging with ultrasound. Front Neurol Neurosci 2015; 36:57-70.
[45] Seidel G, Meyer-Wiethe K. Ultrasound perfusion imaging in acute ischemic stroke. New York: Nova Science; 2007. p1-31.
[46] Kummer T, Oh L, Phelan MB, Huang RD, Nomura JT, Adhikari S. Emergency and critical care applications for contrast-enhanced ultrasound. Am J Emerg Med 2018; 36:1287-1294.
[47] Ayoub J. Contribution of CEUS in the diagnosis in emergency trauma and ICU. Ultrasound Med Biol 2015; 41:S67-S68
[48] Gummadi S, Koenig G, Wessner CE, Machado P, Stem J, Forsberg F, et al. Contrast-enhanced ultrasound in small intestinal ischemia: proof of concept. J Ultrasound Med 2022; 41:835-843.
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