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Advanced Ultrasound in Diagnosis and Therapy ›› 2025, Vol. 9 ›› Issue (3): 254-259.doi: 10.26599/AUDT.2025.240068

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  • 收稿日期:2024-11-27 修回日期:2025-02-02 接受日期:2025-03-06 出版日期:2025-09-30 发布日期:2025-10-13

Application of Two-Dimensional Speckle Tracking Echocardiography in Evaluation of Neonatal Pulmonary Hypertension

Feng Qinga,b,c, Yang Huihuia,b,c, Xu Wantinga,b,c, He Yua,b,c,*()   

  1. aDepartment of Ultrasound, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, Guangdong, China
    bGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, Guangdong, China
    cThe Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
  • Received:2024-11-27 Revised:2025-02-02 Accepted:2025-03-06 Online:2025-09-30 Published:2025-10-13
  • Contact: Department of Ultrasound, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital, Guangzhou Medical University, 63 Duobao street, Guangzhou, China. e-mail:2022683036@gzhmu.edu.cn(Y H)

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Abstract:

Objective It is always a clinical challenge to identify neonatal pulmonary hypertension (NPH). Although the diagnostic gold standard of pulmonary hypertension (PH) is the true measurement of resting pulmonary arterial pressure (PAP) through cardiac catheterization, it is inappropriate for delicate newborns. Hence, echocardiography examination has become the most common inspection tool for NPH despite its limitations.
Methods After outlining the conventional echocardiographic parameters for detecting NPH and their drawbacks in newborns, this review mainly discussed the roles of two-dimensional speckle tracking echocardiography, including RV global longitudinal strain and segmental longitudinal strain, in the evaluation of NPH, hoping to provide more information for detecting NPH.
Results When combined with conventional echocardiographic parameters, RV longitudinal strain would be a great help for the evaluation of NPH. Furthermore, based on the preliminary research, our finding revealed that the magnitude of the apical segmental strain of RVFW was significantly lower, and the basal-to-apical strain ratio (Ratio bas/api) of RVFW was remarkably higher in infants with PH than those without PH.
Conclusion Based on the particularity of newborns, neonatal echocardiography is the preferred inspection method for NPH. It provides hemodynamic, morphological and functional information for evaluating NPH. RV longitudinal strain is sensitive to subtle changes of RV function and closely related to PH. It could be considered not only as the key factor affecting the prognosis of NPH but also as a potential index to detect and identify NPH.

Key words: Right ventricle, Longitudinal strain, Neonate pulmonary hypertension, Two-dimensional speckle tracking echocardiography

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