[an error occurred while processing this directive]

Advanced Ultrasound in Diagnosis and Therapy ›› 2024, Vol. 8 ›› Issue (3): 124-129.doi: 10.37015/AUDT.2023.230057

• • 上一篇    下一篇

  

  • 收稿日期:2023-11-30 修回日期:2024-01-20 接受日期:2024-02-17 出版日期:2024-09-30 发布日期:2024-10-16

The Diagnostic Value of Real-time Shear Wave Ultrasound Elastography in the Differentiation of Hepatic Hemangioma and Hepatocellular Carcinoma

Yue Tian, MBa,*(), Yanan Zhao, MDb, Yiran Huang, MBc   

  1. aDepartment of Ultrasound, Yongxin Hospital, Xiaoshan District, Hangzhou, Zhejiang, China
    bDepartment of Ultrasound, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    cDepartment of Ultrasound, Yongxin Hospital, Xiaoshan District, Hangzhou, Zhejiang, China
  • Received:2023-11-30 Revised:2024-01-20 Accepted:2024-02-17 Online:2024-09-30 Published:2024-10-16
  • Contact: *Department of Ultrasound,Yongxin Hospital, Xiaoshan District, 11678 Jianshe 4th Road, Guali Town, Xiaoshan District, Hangzhou, Zhejiang, China e-mail:1547552163@qq.com

RichHTML

11

PDF (PC)

95

Abstract:

Objective: To explore the diagnostic value of real-time shear wave elastography (SWE) in hepatic hemangioma (ANGI) and hepatocellular carcinoma (HCC).

Methods: A total of 88 patients diagnosed with angiosarcoma (ANGI) or hepatocellular carcinoma (HCC) in our department from February 2019 to February 2020 were included in this study. These patients were assigned to two groups based on pathological diagnosis: the ANGI group (n = 42) and the HCC group (n = 46). All patients underwent SWE examination, and the clinical efficacy was analyzed by comparing the average value of Young's modulus of the two groups and plotting the receiver operator characteristic (ROC) curve.

Results: There was no significant difference in lesion diameter between ANGI and HCC patients (P > 0.05). The ANGI group exhibited a significantly higher average Young's modulus for both the lesions and the adjacent liver tissues compared to the HCC group (P < 0.001); The area under the curve (AUC) of the average value of Young’s modulus of the lesion to ANGI and HCC was 0.875 (95% CI = 0.795-0.955).

Conclusion: SWE demonstrates high diagnostic accuracy in distinguishing ANGI from HCC, providing valuable clinical evidence for differentiating between the two diseases.

Key words: Shear wave elastography, Hepatic hemangioma, Hepatocellular carcinoma, Diagnosis

"

"

Items ANGI group (n = 42) HCC group (n = 46) χ2/t P value
Gender 0.070 0.792
Male 24 (57.14%) 25 (54.35%)
Female 18 (42.86%) 21 (45.65%)
Age (years) 48.72 ± 5.72 48.81 ± 5.69 0.074 0.941
BMI (kg/m2) 21.14 ± 1.35 21.35 ± 1.46 0.699 0.487
Mean course of disease (months) 11.26 ± 3.26 11.31 ± 3.25 0.072 0.943
Marriage 0.369 0.544
Unmarried 3 (7.14%) 5 (10.87%)
Married 35 (83.33%) 36 (78.26%)
Divorced 4 (9.52%) 5 (10.87%)
Place of residence 0.002 0.969
Urban 19 (45.24%) 21 (45.65%)
Rural 23 (54.76%) 25 (54.35%)
Education level 0.390 0.532
Junior college and above 12 (28.57%) 16 (34.78%)
High school 19 (45.24%) 17 (36.96%)
Middle school and below 11 (26.19%) 13 (28.26%)

"

"

"

"

Detection result variable AUC Standard errora Asymptotic Sig.b Asymptotic 95% confidence interval
Lower limit Upper limite
Average value of Young’s modulus 0.875 0.041 < 0.001 0.795 0.955
[1] Zavras, Nikolaos, Dimopoulou, Anastasia, Machairas, Nikolaos, et al. Infantile hepatic hemangioma: current state of the art, controversies, and perspectives. European journal of pediatrics 2020;179:1-8.
[2] Dong, Wenfang, Qiu, Bin, Xu, Haifeng, et al. Invasive management of symptomatic hepatic hemangioma. European journal of gastroenterology and hepatology 2019;31:1079-1084.
[3] Lekwuttikarn, Ramrada, Josephs, Shellie, Teng, Joyce M. Successful medical management of life-threatening hepatic hemangioma in neonates. Pediatrics: Official Publication of the American Academy of Pediatrics 2019;144:e20191339.
[4] Wendling-Keim, Danielle, Vokuhl, Christian, Walz, Christoph, et al. Activation of hedgehog signaling in aggressive hepatic hemangioma in newborns and infants. Anticancer Research: International Journal of Cancer Research and Treatment 2019;39:2351-2360.
[5] Zhai LL, Ju TF, Zhou CH, Xie Q. Spontaneous rupture of giant hepatic hemangioma: misdiagnosis as gastrointestinal perforation. J Int Med Res 2019;47:4514-4521.
[6] Makamure J, Zhao D, Liu Y, Wang Y, Zheng C, Liang B. Hepatic hemangioma with arterioportal shunt: Prevalence and lesion characteristics based on DSA, CT and MR imaging. Eur J Radiol 2019;121:108715.
[7] Paudice M, Peñuela LA, Torielli F, Spina B, Remorgida V, Buffelli F, et al. Giant hepatic hemangioma and placental chorangiosis: A unique case of stillbirth? Fetal Pediatr Pathol 2019;38:175-181.
[8] Prodromidou A, Machairas N, Garoufalia Z, Kostakis ID, Tsaparas P, Paspala A, et al. Liver transplantation for giant hepatic hemangioma: A systematic review. Transplant Proc 2019;51:440-442.
[9] Luetić T, Radoš M, Vuković J, Grizelj R, Papeš D, Ćavar S, et al. Embolization of a rapidly involuting congenital hepatic hemangioma via the umbilical vein in a neonate. J Vasc Interv Radiol 2019;30:1625-1628.
[10] Watanabe, Shunsuke, Murayama, Mika, Tsuchiya, Tomonori, et al. A case of neonatal giant hepatic hemangioma with kasabach merritt syndrome in addition to congenital duodenal atresia. Pediatric blood & cancer 2019;66:S126.
[11] Choi B, McBride A, Scott AJ. Treatment with pembrolizumab after hypersensitivity reaction to nivolumab in a patient with hepatocellular carcinoma. Am J Health Syst Pharm 2019;76:1749-1751.
[12] Chen DT, Pan JH, Chen YH, Xing W, Yan Y, Yuan YF, et al. The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target. Br J Anaesth 2019;122:E157-E167.
[13] Lei P, Jiao J, Li H, Wang P, Duan Q, Liu J, et al. NAFLD evaluation: Which is more appropriate, multislice computed tomography or ultrasound real-time shear wave elastography? J Xray Sci Technol 2019;27:871-883.
[14] Chung AD. Fat-containing lesions of the liver: A review of differential diagnoses. Can Assoc Radiol J 2020;71:12-18.
[15] Tirosh A, Hamimi A, Faucz F, Aharon-Hananel G, Zavras PD, Bonella B, et al. Liver findings in patients with Carney complex, germline PRKAR1A pathogenic variants, and link to cardiac myxomas. Endocr Relat Cancer 2020;27:355-360.
[16] Spużak J, Kubiak K, Glińska-Suchocka K, Jankowski M, Borusewicz P, Kubiak-Nowak D.. Accuracy of real-time shear wave elastography in the assessment of normal small intestine mucosa in dogs. Pol J Vet Sci 2019;22:457-461.
[17] Näkkäläjärvi I, Hakko H, Riala K, Riipinen P. Substance dependence and hepatitis among tramadol prescription users: A study of former adolescent psychiatric inpatients in northern finland. J Psychoactive Drugs 2020;52:162-168.
[18] Shan S, Wei W, Kong Y, Niu J, Shang J, Xie W, et al. China registry of hepatitis B (CR-HepB): Protocol and implementation of a nationwide hospital-based registry of hepatitis B. Scand J Public Health 2020;48:233-239.
[19] Oprea, Maria Cristina, Vlad, Mihaela, Golu, Ioana, et al. Diagnostic value of real-time shear wave elastography in diagnosing thyroid cancer. Revista de Chimie 2017;68:2818-2822.
[20] Guo Y, Gao P, Wang H, Wu J, Bai Q, Huang L, et al. Risk factors of hepatitis B virus infection between vaccinated and unvaccinated groups among spouses in 2006 and 2014: a cross-sectional study in Beijing. Hum Vaccin Immunother 2020;16:148-157.
[21] Johannsen S, Türkmeneli I, Isbary S, Roewer N, Schuster F. Ultrasound elastography for rapid, real-time detection of localized muscular reaction in malignant hyperthermia-susceptible pigs. Anesthesiology 2018;129:989-999.
[22] Aljuraifani R, Stafford RE, Hug F, Hodges PW. Female striated urogenital sphincter contraction measured by shear wave elastography during pelvic floor muscle activation: Proof of concept and validation. Neurourol Urodyn 2018;37:206-212.
[23] Sugiura A, Joshita S, Yamashita Y, Yamazaki T, Fujimori N, Kimura T, et al. Effectiveness of glecaprevir/pibrentasvir for hepatitis C: Real-world experience and clinical features of retreatment cases. Biomedicines 2020;8:74.
[24] Vachutka J, Sedlackova Z, Furst T, Herman M, Herman J, Salzman R, et al. Evaluation of the effect of tissue compression on the results of shear wave elastography measurements. Ultrason Imaging 2018;40:380-393.
[25] Yang Y, Qiu L, Wang L, Xiang X, Tang Y, Li H, et al. Quantitative assessment of skin stiffness using ultrasound shear wave elastography in systemic sclerosis. Ultrasound Med Biol 2019;45:902-912
No related articles found!
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
[an error occurred while processing this directive]