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Advanced Ultrasound in Diagnosis and Therapy ›› 2024, Vol. 8 ›› Issue (1): 7-14.doi: 10.37015/AUDT.2024.230060

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  • 收稿日期:2023-12-11 接受日期:2024-01-04 出版日期:2024-03-30 发布日期:2024-02-04

Clinical Application of Ultrasound Tomography in Diagnosis of Musculoskeletal Diseases

Cong Wei, MDa,1, Hui Zhang, PhDc,1, Tao Ying, MDa, Bing Hu, MDa, Yini Chen, MDa, Hongtao Li, MDb, Qiude Zhang, PhDc, Mingyue Ding, PhDc, Jie Chen, MDa,*(), Ming Yuchi, PhDc,*, Yuanyi Zheng, MDa,*   

  1. aDepartment of Medical Ultrasound, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai, China
    bDepartment of Oncology in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    cDepartment of Bio-medical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
  • Received:2023-12-11 Accepted:2024-01-04 Online:2024-03-30 Published:2024-02-04
  • Contact: Department of Bio-medical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Hongshan District, Wuhan, China (M. YC); Department of Medical Ultrasound, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China (J. C and Y. Z).email: zhengyuanyi@163.com (Y.Z)
  • About author:First author contact:1 C.W. and H.Z. contributed equally to this study.

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Abstract:

Objective To evaluate the feasibility and capability of UT in detecting musculoskeletal system lesions in the limbs and to explore its image quality.

Materials and Methods The Institutional Review Board has approved this prospective single-center study. This study included participants with various musculoskeletal and neurologic disorders in the limbs who provided written consent from October 2022 to April 2023. In addition to other radiological examinations (X-rays, CT, or MRI) and conventional handheld ultrasound scans requested by clinicians based on the conditions, each participant also underwent UT scanning using our developed limb ultrasound imaging system during the same period. Four radiologists and ultrasound physicians with more than five years of experience in musculoskeletal diagnostics analyzed the two-dimensional and three-dimensional images of the examination area.

Results Overall, 50 participants were evaluated (mean age, 36 years ± 18 [SD]; 26 males). The conditions included musculoskeletal tumors (n = 10), postoperative follow-up of musculoskeletal tumors (n = 20), peripheral nerve disorders in the limbs (n = 10) and postoperative pain in orthopedic surgery (n = 10). In all UT images, the region of interest was completely displayed, and internal structures such as muscles and nerves were clearly visible. Compared to conventional ultrasound images, the reconstructed three-dimensional images intuitively displayed the relationship between the lesions and surrounding tissues. Furthermore, UT did not exhibit metal artifacts when observing soft tissues around metallic implants, providing more comprehensive soft tissue information and more intuitive stereoscopic images.

Conclusion Clinical results of the UT system have demonstrated its feasibility as an automated and standardized imaging technique for musculoskeletal imaging, providing a new imaging modality for the diagnosis of musculoskeletal diseases in the human body.

Key words: Ultrasound tomography, Musculoskeletal imaging, Tumors, Arthroplasty, Neuropathy

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Characteristic Value (n = 50)
Age (y)* 36 ± 18 (11-69)
Sex
M 26 (52)
F 24 (48)
Indication for UT examination
Musculoskeletal tumors 10 (20)
Peripheral nerve disorders 10 (20)
Postoperative follow-up of tumors 20 (40)
Postoperative pain following orthopedic implant surgery 10 (20)

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[1] Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. lobal estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 2021; 396:2006-2017.
doi: 10.1016/S0140-6736(20)32340-0
[2] Igrec J, Fuchsjäger MH. Imaging of bone sarcomas and soft-tissue sarcomas. Rofo 2021; 193:1171-1182.
doi: 10.1055/a-1401-0215 pmid: 33772487
[3] Khodarahmi I, Fishman EK, Fritz J. Dedicated CT and MRI techniques for the evaluation of the postoperative knee. Semin Musculoskelet Radiol 2018; 22:444-456.
doi: 10.1055/s-0038-1653955 pmid: 30134468
[4] Irwig L, Houssami N, van Vliet C. New technologies in screening for breast cancer: a systematic review of their accuracy. Br J Cancer 2004; 90:2118-2122.
doi: 10.1038/sj.bjc.6601836
[5] Ulrich IE, Boehm C, Zunino A, Bösch C, Fichtner A. Diffuse ultrasound computed tomography. J Acoust Soc Am 2022; 151:3654-3668.
doi: 10.1121/10.0011540 pmid: 35778223
[6] Sandhu GY, Li C, Roy O, Schmidt S, Duric N. Frequency domain ultrasound waveform tomography: breast imaging using a ring transducer. Phys Med Biol 2015; 60:5381-5398.
doi: 10.1088/0031-9155/60/14/5381 pmid: 26110909
[7] Wang S, Zou X, Zeng L, Song J, Zhou L, Ding M, et al. Combination of variational mode decomposition and coherent factor for ultrasound computer tomography. Technol Health Care 2022; 30:163-171.
doi: 10.3233/THC-228016 pmid: 35124594
[8] Fang X, Zhou R, Gan H, Ding M, Yuchi M. Time-of-flight completion in ultrasound computed tomography based on the singular value threshold algorithm. Math Biosci Eng 2022; 19:10160-10175.
doi: 10.3934/mbe.2022476 pmid: 36031989
[9] Opieliński KJ, Pruchnicki P, Gudra T, Podgórski P, Kurcz J, Kraśnicki T, et al. Imaging results of multi-modal ultrasound computerized tomography system designed for breast diagnosis. Comput Med Imaging Graph 2015;46 Pt 2:83-94.
[10] Hollenhorst M, Hansen C, Hüttebräuker N, Schasse A, Heuser L, Ermert H, et al. Ultrasound computed tomography in breast imaging: first clinical results of a custom-made scanner. Ultraschall Med 2010; 31:604-609.
doi: 10.1055/s-0029-1245506
[11] Falardeau T, Belanger P. Ultrasound tomography in bone mimicking phantoms: Simulations and experiments. J Acoust Soc Am 2018; 144:2937.
doi: 10.1121/1.5079533 pmid: 30522285
[12] Wiskin J, Malik B, Borup D, Pirshafiey N, Klock J. Full wave 3D inverse scattering transmission ultrasound tomography in the presence of high contrast. Sci Rep 2020; 10:20166.
doi: 10.1038/s41598-020-76754-3 pmid: 33214569
[13] Carson PL, Meyer CR, Scherzinger AL, Oughton TV. Breast imaging in coronal planes with simultaneous pulse echo and transmission ultrasound. Science 1981; 214:1141-1143.
pmid: 7302585
[14] Schreiman JS, Gisvold JJ, Greenleaf JF, Bahn RC. Ultrasound transmission computed tomography of the breast. Radiology 1984; 150:523-530.
pmid: 6691113
[15] Pei Y, Zhang G, Zhang Y, Zhang W. Breast acoustic parameter reconstruction method based on capacitive micromachined ultrasonic transducer array. Micromachines (Basel) 2021; 12:963.
[16] Li C, Duric N, Littrup P, Huang L. In vivo breast sound-speed imaging with ultrasound tomography. Ultrasound Med Biol 2009; 35:1615-1628.
doi: 10.1016/j.ultrasmedbio.2009.05.011 pmid: 19647920
[17] Kratkiewicz K, Pattyn A, Alijabbari N, Mehrmohammadi M. Ultrasound and photoacoustic imaging of breast cancer: clinical systems, challenges, and future outlook. J Clin Med 2022; 11:1165.
doi: 10.3390/jcm11051165
[18] Sanabria SJ, Ozkan E, Rominger M, Goksel O. Spatial domain reconstruction for imaging speed-of-sound with pulse-echo ultrasound: simulation and in vivo study. Phys Med Biol 2018; 63:215015.
doi: 10.1088/1361-6560/aae2fb
[19] Ruiter NV, Zapf M, Hopp T, Dapp R, Kretzek E, Birk M, et al. 3D ultrasound computer tomography of the breast: a new era. Eur J Radiol 2012; 81 Suppl 1:S133-S134.
[20] Park EY, Cai X, Foiret J, Bendjador H, Hyun D, Fite BZ, et al. Fast volumetric ultrasound facilitates high-resolution 3D mapping of tissue compartments. Sci Adv 2023; 9:eadg8176.
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