Ultrasound has developed as an invaluable tool in diagnosis and proper management in the critical care settings. There are four aspects of applying critical care ultrasonography, including substitutional ultrasound, predicational ultrasound, point-of-care ultrasound, and whole body ultrasound. All four aspects have been widely applied in Wuhan based on the special ultrasound lump test predicational critical patients (ULTPCP) protocol. We aim to introduce our own experience of utilizing critical care ultrasound to significantly improve outcomes, shorten the operation time, and reduce occupational exposure.