Top 10 click
Published in last 1 year |  In last 2 years |  In last 3 years |  All
Please wait a minute...
For Selected: Toggle Thumbnails
Renal Contrast-enhanced Ultrasound: Clinical Applications and Emerging Research
Felipe Velasquez-Botero, MD, Ananya Balasubramanya, Ying Tang, MD, Qiang Lu, MD, Ji-Bin Liu, MD, John R. Eisenbrey, PhD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 129-146.   DOI: 10.37015/AUDT.2022.220036
Abstract401)   HTML31)    PDF(pc) (7061KB)(470)       Save

Contrast-enhanced ultrasound (CEUS) is an imaging modality that has achieved considerable relevance in various clinical settings including the assessment of renal disease. CEUS is performed by injecting microbubble-based ultrasound contrast agents (UCAs) that create signals to display the microvasculature, allowing quantitative and qualitative assessment of parenchymal perfusion and real-time visualization of the renal anatomy. In recent years, CEUS has been widely accepted and applied for the assessment of kidney perfusion and the characterization of indeterminate renal masses, primarily due to its diagnostic efficacy, availability, low cost, reproducibility, and absence of nephrotoxicity. CEUS provides a higher spatial and temporal resolution than other cross-sectional imaging, resulting in high sensitivity and specificity for its applications in a variety of renal conditions including cancer monitoring following ablation, detection of transplant complications, hypoperfusion, acute traumatic injury, renal artery stenosis, parenchymal infection, and kidney intervention guidance. Additionally, the continuous investigation and development of new technologies surrounding this imaging technique have shown encouraging preliminary results for the use of CEUS in the evaluation of molecular expression in several disease processes, the dynamic analysis of blood flow kinetics, and the implementation of super-resolution imaging systems. The purpose of this article is to provide an overview of the current and potential clinical applications of renal CEUS.

Table and Figures | Reference | Related Articles | Metrics
Diagnostic Performance of Superb Microvascular Imaging for Breast Masses: A Systematic Review and Meta-analysis
Zehui Fu, MD, Siqi Wang, MD, Jian Zhang, MD, Yejun Lu, MD, Xiaomin Mo, MD, Ye He, MD, Chong Wang, MD, Hui Chen, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 95-103.   DOI: 10.37015/AUDT.2022.210028
Abstract285)   HTML40)    PDF(pc) (749KB)(383)       Save

Objective: In the present study, we aimed to evaluate the diagnostic performance of superb microvascular imaging (SMI) for breast masses through a meta-analysis.

Methods: PubMed, EMBASE, Cochrane Library, and Web of Science Core Collection databases, as well as the most comprehensive Chinese academic databases in medicine, such as China Biology Medicine Disc, China National Knowledge Infrastructure, and Wanfang Database, were systematically searched. All included studies used histopathological results as the reference standard. To assess the diagnostic performance, we calculated the pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), diagnostic odds ratio (DOR), and the area under the curve (AUC). In addition, a subgroup meta-regression analysis was performed to investigate the heterogeneity.

Results: Fourteen of 1,075 identified articles were included in the current review. The pooled sensitivity, specificity, LR+, LR-, and DOR for SMI were 0.85 (95% CI: 0.79-0.89), 0.80 (95% CI: 0.71-0.87), 4.3 (95% CI: 2.9-6.2), 0.19 (95% CI 0.14-0.26), and 22 (95% CI: 14-36), respectively. The AUC was 0.90 (0.87 - 0.92). Meta-regression showed that there were heterogeneities for sensitivity, but not for specificity.

Conclusions: SMI had good sensitivity, specificity, and excellent diagnostic value in distinguishing benign breast masses from malignant masses and could potentially help select suspicious breast masses for surgery.

Reference | Related Articles | Metrics
Contrast-enhanced Ultrasound for Evaluation of Active Needle Tract Bleeding during Thermal Ablation of Liver Cancer
Huolin Ye, MD, Qiannan Huang, MD, Qingjing Zeng, MD, Xuqi He, MD, Erjiao Xu, MD, Yinglin Long, MD, Kai Li, MD, Rongqin Zheng, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 104-111.   DOI: 10.37015/AUDT.2021.210019
Abstract277)   HTML20)    PDF(pc) (2296KB)(377)       Save

Objective: To investigate the accuracy of contrast-enhanced ultrasound (CEUS) in the diagnosis and localization of active needle-tract bleeding (ANTB) during thermal ablation for liver cancer.

Methods: Between June 2013 and December 2018, liver cancer patients with poor coagulation function or suspected needle-tract bleeding during ablation were enrolled in the study. Conventional US and CEUS were applied to detect ANTB and the bleeding sites, and sequentially abdominal paracentesis drainage (APD) was used as the gold standard for the diagnosis of ANTB. Thermal ablation guided by conventional US or CEUS was used to stop the bleeding.

Results: Among the 77 enrolled patients, 21 patients (27.3%, 21/77) had ANTB. In total, four (19.0%) and 21 (100%) cases of ANTB were diagnosed by colour Doppler US and CEUS, respectively. The sensitivity, specificity and accuracy of colour Doppler US for diagnosing ANTB were 19.0%, 100% and 77.6%, respectively. The sensitivity, specificity, and accuracy of CEUS for diagnosing ANTB were 100%, 100% and 100%, respectively. The sensitivity of CEUS to diagnose ANTB was significantly higher than that of colour Doppler US (P < 0.001). All cases of ANTB were arterial bleeding and were stopped by thermal ablation under the guidance of colour Doppler US or CEUS.

Conclusion: Compared to colour Doppler US, CEUS could detect ANTB with significantly higher sensitivity and accurately guide needle-tract ablation during thermal ablation of liver cancer.

Reference | Related Articles | Metrics
Research Progress in Ultrasonic Regulation of Cholinergic Anti-inflammatory Pathway
Wuqi Zhou, MD, Yishu Song, MD, Rui Wang, MD, Qiaofeng Jin, MD, Mingxing Xie, PhD, Li Zhang, PhD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 147-152.   DOI: 10.37015/AUDT.2022.200034
Abstract263)   HTML7)    PDF(pc) (521KB)(340)       Save

The cholinergic anti-inflammatory pathway is a neuro-immune regulatory pathway that mediates anti-inflammatory effects based on the vagus nerve, acetylcholine and α7 nicotinic acetylcholine receptors. In recent years, the effect of nerve stimulation by ultrasound has attracted much attention and has been widely studied. Ultrasound can stimulate the vagus nerve or spleen nerve and activate the cholinergic anti-inflammatory pathway, exerting anti-inflammatory and organ protection effects, which is expected to provide a new treatment for many inflammatory diseases. The purpose of this review is to introduce the composition, mechanisms and regulation methods of cholinergic anti-inflammatory pathway, and discuss its therapeutic implications.

Table and Figures | Reference | Related Articles | Metrics
Functional Brain Imaging Based on the Neurovascular Unit for Evaluating Neural Networks after Stroke
Yongyue Zhang, MM, Yang Sun, MM, Li Zhang, MM, Rongjin Zhang, MM, Shumin Wang, PhD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 153-164.   DOI: 10.37015/AUDT.2022.210033
Abstract258)   HTML7)    PDF(pc) (681KB)(349)       Save

The exploration of human brain function has always been a research hotspot in the field of neuroscience. The concept of a neurovascular unit suggests that cerebral microcirculation can be used as a reliable signal to reflect neural function. Accordingly, functional imaging techniques based on the neurovascular unit are very promising because of their ability to reveal neurovascular coupling and evaluate the functional rehabilitation of cerebrovascular diseases represented by stroke. In the present review, we first describe the role of the neurovascular unit in the injury and repair processes after stroke. We then briefly introduce the relative characteristics and advantages of representative neurovascular unit-based functional imaging. Finally, we summarized the value of these techniques in the evaluation of neural networks after stroke.

Table and Figures | Reference | Related Articles | Metrics
Guidelines for Echocardiographic Diagnosis of Cardiomyopathy: Recommendations from Echocardiography Group of Ultrasound Medicine Branch in Chinese Medical Association, Echocardiography Committee of Cardiovascular Branch in Chinese Medical Association
Echocardiography Group of Ultrasound Medicine Branch in Chinese Medical Association, Echocardiography Committee of Cardiovascular Branch in Chinese Medical Association
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 72-94.   DOI: 10.37015/AUDT.2022.210021
Abstract239)   HTML15)    PDF(pc) (22607KB)(132)       Save
Reference | Related Articles | Metrics
Diagnostic Values of CEUS, CECT and CEMRI for Renal Cystic Lesions on the Current Bosniak Criterion-A Meta-analysis
Xiaojuan Yang, MD, Huihui Yang, MD, Yu He,MD, PhD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 165-173.   DOI: 10.37015/AUDT.2022.210037
Abstract238)   HTML4)    PDF(pc) (1102KB)(297)       Save

Objective: CT-based Bosniak classification system has been routinely used to assess complex renal cystic lesions and also been applied to contrast-enhanced magnetic resonance imaging (CEMRI) and contrast-enhanced ultrasound (CEUS). Besides, the 2019 new version incorporated MRI into the Bosniak system. However, the role of US in the Bosniak system has not been clearly established. The aim of this study was to compare the diagnostic ability of CEUS, CECT and CEMRI for renal cystic lesions based on the current Bosniak classification.

Methods: Related studies were searched in PubMed, EMBASE, and the Cochrane Library databases from January 1, 2010 to December 14, 2020. QUADAS-2 was used to assess the study quality. Meta-analysis was performed by “midas modules” of Stata SE 15.0 software. The bivariate mixed-effect model was used. The pooled sensitivity and specificity of these three modalities were calculated and compared. Meta-regression and subgroup analyses were conducted to reveal the source of heterogeneity.

Results: CEUS showed highest pooled sensitivity and specificity, which were 98% (95% CI: 91%, 100%) and 80% (95% CI: 64%, 90%) respectively. Pooled estimates of CEMRI were slightly lower than those of CECT with the sensitivity 85% (95% CI: 77%, 91%) versus 88% (95% CI: 77%, 94%) and specificity 71% (95% CI: 52%, 85%) versus 79% (95% CI: 70%, 86%), respectively.

Conclusions: Based on the current Bosniak classification, CEUS seemed superior to CECT and CEMRI for the diagnosis of complex renal cystic masses, and could serve as a valuable alternative for CECT and CEMRI.

Table and Figures | Reference | Related Articles | Metrics
Performance of Elastography, Color Doppler and B Mode Ultrasound to Differentiate Fibroadenomas from Phyllodes Tumors
Lynda Aoudia, Amal Kouchkar, Salah Eddine Bendib
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 195-203.   DOI: 10.37015/AUDT.2022.220003
Abstract229)   HTML6)    PDF(pc) (2261KB)(265)       Save

Objective: To evaluate and compare the diagnostic performance of B-mode ultrasound (B-mode US), strain elastography (SE), color Doppler ultrasound (color Doppler US) and the combination of these modalities in differentiation between fibroadenomas and phyllodes tumors.

Methods: This retrospective study included 220 breast lesions, between January 2016 and January 2018. B-mode US, strain elastography, and color Doppler US were realized to evaluate each lesion. The results of three modalities were compared between the B-mode US and the combination of B-mode US, elastography, and color Doppler US: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC). The pathological findings were used as the reference standard.

Results: Among 220 breast masses, 189 of the lesions were fibroadenomas, 31 were phyllodes tumors. Addition of strain elastography and color Doppler US to B-mode US increased the specificity from 27.5% (95% confidence interval [CI]: 21.15%, 33.88%) to 95.24% (95% CI: 92.20%, 98.27%; P < 0.001); PPV from 16.46% (95% CI: 10.79%,22.14%) to 60.87% (95% CI: 40.92%, 80.82%; P < 0.001) and AUC from 0.584 (95% CI: 0.481, 0.687) to 0.886 (95% CI: 0.824, 0.948; P < 0.001).

Conclusion: The combination B-mode US, strain elastography and color Doppler US increase the diagnostic performance in distinguishing fibroadenomas from phyllodes tumors.

Table and Figures | Reference | Related Articles | Metrics
Using S-Detect to Improve Breast Ultrasound: The Different Combined Strategies Based on Radiologist Experience
Ying Zhu, MD, Xiaohong Jia, MD, Yijie Dong, MD, Juan Liu, MD, Yilai Chen, MD, Congcong Yuan, MD, Weiwei Zhan, MD, Jianqiao Zhou, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 180-187.   DOI: 10.37015/AUDT.2022.220007
Abstract225)   HTML3)    PDF(pc) (1224KB)(334)       Save

Objective: To investigate the best combined method of S-Detect, a computer-aided diagnosis (CAD) system, with breast ultrasound (US) according to radiologists’ experience.

Methods: From March 2019 to June 2019, 259 breast masses in 255 women were included in this study. Ultrasonographic images of the target masses were prospectively analyzed by radiologists and CAD. Three combined methods, including method 1 [selective downgrading combination for Breast Imaging Reporting and Data System (BI-RADS) 4a lesions], method 2 (selective upgrading combination for BI-RADS 3 lesions) and method 3 (selective upgrading or downgrading combination for BI-RADS 3 or 4a lesions), were applied to interpret the CAD results. The sensitivity, specificity, the area under the receiver operating characteristic curve (AUC) of experienced or inexperienced radiologists before and after adding CAD results were compared using the histopathological results as a reference standard.

Results: In identifying breast malignancy, the AUC for CAD was similar to that of experienced radiologists (P= 0.410), but higher than that of inexperienced radiologists (P= 0.003). When combining CAD with experienced radiologists based on method 1 and combining CAD results with inexperienced radiologists based on method 3, the AUCs were significantly improved (P= 0.024 and 0.003, respectively) compared to US alone, with significantly increased specificity (P< 0.001 for both) and no significantly decreased sensitivity (P> 0.05 for both).

Conclusion: The combination of CAD system and conventional ultrasound can improve ultrasound diagnostic performance in determining breast malignancy. The method 1 and method 3 combinations are respectively recommended for experienced and inexperienced radiologists when CAD is combined with conventional breast ultrasound.

Table and Figures | Reference | Related Articles | Metrics
Uterine Artery Pseudoaneurysm after Cesarean Section Treated with Superselective Embolization: A Case Report
Jullie Anne Chiste, Larissa Cavalli de Oliveira, Liziane Lorusso, Anna Luisa Aranha Nunes, João Vitor Bacarin
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 210-213.   DOI: 10.37015/AUDT.2022.210031
Abstract225)   HTML2)    PDF(pc) (818KB)(322)       Save

Uterine artery pseudoaneurysm is a rare complication associated with obstetric or gynecological procedures. We described a case report of a primigravid, underwent cesarean section who evolved with massive, intermittent vaginal bleeding requiring multiple blood transfusions. The diagnosis of uterine artery pseudoaneurysm was suspected on transvaginal Doppler ultrasound and confirmed on computed tomography angiography. Due to the patient's stability, age and undefined offspring, superselective uterine artery embolization was chosen for treatment and the procedure successfully performed.

Table and Figures | Reference | Related Articles | Metrics
Peripheral Nerve Lipomatosis: Pathology, Clinical Features, Imaging Diagnosis and Treatment
Ping Xu, MM, Heping Deng, MD, Bo Lu, MD, Yaru Mi, MM
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 174-179.   DOI: 10.37015/AUDT.2022.210039
Abstract223)   HTML5)    PDF(pc) (2703KB)(293)       Save

This article provides a review of pathology, clinical features, imaging diagnosis and treatment of lipomatosis of nerve (LN), aiming to improve the comprehensive understanding of the disease and achieve early diagnosis and treatment. By searching for the relevant literature, we systematically summarized the pathology, clinical features, imaging diagnosis and treatment of LN in peripheral nerve. Lipomatosis of nerve is a rare benign tumor-like lesion in the peripheral nerve. LN can present primarily as painless neoplasm, macrodactyly, or neurological dysfunction. Magnetic resonance imaging and ultrasonography are commonly used imaging methods before operation, which can characterize and locate the scope of the disease. There are few ultrasonographic studies on LN of peripheral nerve, mostly in the form of case report or small sample analysis. Treatment of lipomatosis of nerve varies with clinical symptoms and lacks consensus. Although LN is benign lesion, it can be invasive, progressive, and recurrent. It is very important to understand the problems of neurological dysfunction caused by LN. More studies are needed to provide more detailed imaging information for clinicians and to achieve the effective treatment.

Table and Figures | Reference | Related Articles | Metrics
Contrast-enhanced Ultrasound Features of Lymphoepithelioma-Like Cholangiocarcinoma with Multiple Metastases: A Case Report
Guiwu Chen, MS, Wenqin Liu, MS, Zhizhong He, PhD, Xiaomin Liao, MS, Yuhuan Xie, PhD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 122-124.   DOI: 10.37015/AUDT.2021.210027
Abstract222)   HTML12)    PDF(pc) (1160KB)(309)       Save

Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is an intrahepatic cholangiocarcinoma with a prominent lymphoid infiltrate. According to previous reports, most LEL-CCs are a single lesion with a notably better prognosis compared to typical liver cancers. However, most literature reported pathological features and lacked imaging features, especially that of ultrasound. We report on a 74-year-old female with LEL-CC presented with headache and malaise for six months. We performed superficial ultrasonography, abdominal ultrasonography, hepatic contrast-enhanced ultrasound, positron emission tomography-computed tomography, and ultrasound-guided biopsy. We definitively diagnosed LEL-CC with multiple metastases in the liver, skeleton, and lymph nodes.

Reference | Related Articles | Metrics
Ultrasound Features of Thyroid Metastatic Tumors from the Digestive System: A Report of 2 Cases
Chao Zhang, BS, Yingying Li, MD, Mingbo Zhang, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 217-222.   DOI: 10.37015/AUDT.2022.220021
Abstract210)   HTML0)    PDF(pc) (2472KB)(333)       Save

Thyroid metastatic tumors are a series of rare clinical disease with an incidence of approximately 1.4-3%, of which metastatic tumor from the digestive system is even rarer. Thyroid metastatic tumor from the digestive system is characterized by a rapid growth tumor with high invasiveness and poor prognosis. Ultrasound (US) and contrast-enhanced ultrasound (CEUS) could provide more information for making diagnosis, determining lesion range, and offering biopsy guidance. Ultrasound-guided core needle biopsy (CNB) should be used instead of fine needle aspiration (FNA) to confirm the pathological diagnosis. Here, we report two cases of thyroid metastatic tumor from the digestive system. By describing these cases, we aimed to assess the clinical value of conventional US and CEUS in the diagnosis and treatment of these tumors.

Table and Figures | Reference | Related Articles | Metrics
Ultrasound and Color Doppler Flow Imaging of Paratesticular Leiomyoma
Nianyu Xue, MM, Yaya Chen, MD, Guoyao Wang, BS, Shengmin Zhang, BS
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 119-121.   DOI: 10.37015/AUDT.2021.210022
Abstract204)   HTML4)    PDF(pc) (836KB)(303)       Save

Objective: In this paper, we retrospectively analyzed the ultrasonographic features of paratesticular leiomyoma to help doctors correctly diagnose the disease before operation and guide surgical treatment.

Methods: From 2013 to 2020, 16 cases of paratesticular leiomyomas confirmed by pathology in our hospital were retrospectively analyzed. The retrospective analysis included the ultrasound and color Doppler flow imaging (CDFI) of paratesticular leiomyoma which were evaluated by two experienced radiologists based on the features of ultrasound images of lesions.

Results: All the 16 paratesticular leiomyoma presented as hypoechoic masses with a clear boundary and round shape. The echotexture of 6 large leiomyomas showed a typical vortex appearance. In the remaining 10 small leiomyomas, thin cord-like hyper-echogenic appearance was found. Color Doppler flow imaging showed that the blood flow signal within a large leiomyoma mass (n = 1) was significantly higher than that of surrounding testis while the blood flow signals of the smaller leiomyomas (n = 5) had significantly less flow signals compared with the testis. The remaining leiomyoma masses (n = 10) had similar flow signals to the testicular blood flow.

Conclusion: Sonography can be used to detect testicular tumors and to differentiate extratesticular from intratesticular masses. The ultrasound features of paratesticular leiomyoma included hypo- and hyperechoic mass, a round or typical vortex shape as well as various vascularity based on the size of the tumors.

Reference | Related Articles | Metrics
Ultrasound of Pancreaticoduodenal Pseudoaneurysm without Obvious Cause, A Case Report
Zi’ang Yang, BS, Xia Xu, BS
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 125-127.   DOI: 10.37015/AUDT.2022.210029
Abstract203)   HTML8)    PDF(pc) (784KB)(337)       Save

Pancreaticoduodenal pseudoaneurysm, accounting for only 2% of visceral aneurysms, is a rare but fatal clinical entity. It is a common complication associated with chronic pancreatitis. We here present a case of a 63-year-old Chinese man, who was diagnosed with pancreaticoduodenal pseudoaneurysm by ultrasound and CT. His past medical history was unremarkable, and no obvious cause of the disease could be found. The patient was treated successfully with endovascular embolization using microcoils with no clinical complications.

Reference | Related Articles | Metrics
Contrast-enhanced Ultrasound of Undifferentiated Embryonal Sarcoma of the Liver in Adult: Two Cases Report and Literature Review
Yanling Chen, MM, Hantao Wang, MM, Hong Han, PhD, Yi Dong, PhD, Wen-ping Wang, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 204-209.   DOI: 10.37015/AUDT.2022.220014
Abstract201)   HTML5)    PDF(pc) (2507KB)(333)       Save

Undifferentiated embryonal sarcoma of the liver (UESL) is an aggressive mesenchymal tumor, which presents a low incidence in adults. The low morbidity and atypical clinical manifestations conduce to difficulty in preoperative diagnosis. Imaging manifestations of this tumor is important for its identification. Contrast-enhanced ultrasound (CEUS) was a promising tool to characterize hepatic lesions and proved to have high diagnostic accuracy. The present study reported the CEUS characteristics of UESL in two adult patients, which exhibited peripheral rim hyper-enhancement along with progressively centripetal enhancement and large areas of perfusion defection. Sonographers should be fully aware of this rare disease for better differential diagnosis.

Table and Figures | Reference | Related Articles | Metrics
Appendicular Mucocele: A Rare Diagnosis Made by Use of Ultrasound and Its Histopathological Correlation
Sachin Khanduri, Surbhi , Ashkrit Gupta, Harleen Chawla, Asif Khan, Vaibhav Pathak, Saim Ali Siddiqui, Shahnawaz , Shreya Chitravanshi, Rohit
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 214-216.   DOI: 10.37015/AUDT.2022.220019
Abstract200)   HTML4)    PDF(pc) (1277KB)(287)       Save

Appendiceal mucocele is a rare disease. Sometimes it is discovered accidentally and sometimes it resembles acute appendicitis. The incidence is 0.2% to 0.7% of all appendectomies specimens. A case report of A 35-year female presented to the emergency room with a history of progressively increasing abdominal pain on and off for 3 months. Tenderness in the right lower quadrant of the abdomen was noted with a palpable mass in the right iliac fossa. An abdominal ultrasound examination was performed, and the patient was found to have an Appendicular mucocele-onion peel sign (sonographic layering within a cystic mass). The patient underwent surgery, and the diagnosis was confirmed by the histopathological report. If mucocele is treated incorrectly, pseudomyxoma peritonei which is characterized by a malignant process may develop. The term mucocele is widely used in diagnosing both benign and malignant lesions.

Table and Figures | Reference | Related Articles | Metrics
Graphene Oxide/Polylactic Acid Microbubbles for Efficient Removal of Lead Ions from Aqueous Solution
Meng Han, MD, Ruirui Kang, MD, Juanjuan Chen, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 188-194.   DOI: 10.37015/AUDT.2022.210030
Abstract198)   HTML1)    PDF(pc) (733KB)(248)       Save

Objective: Heavy metal pollution has become one of the environmental contamination problems in today's world. Adsorption materials can effectively remove heavy metal ions from the water. There are some shortcomings for traditional adsorbents, such as difficult separation after adsorption, long separation time, and may cause secondary pollution in the environment without recycling. The aim of this study was to seek new materials with effective ways to absorb heavy metal ions in the water.

Methods: A new kind of adsorption material consisted of polylactic acid (PLA) microbubble and graphene oxide (GO) (i.e., PLA@GO microbubbles) was fabricated which can combine by electrostatic adsorption with the assistance of PAH. The influence of the initial concentration of heavy metal of lead ion, pH value, and absorption time on the adsorption effect of PLA@GO microbubbles was tested in this study.

Results: Graphene oxide modified on PLA microbubble has huge specific surface area and various functional groups, which can adsorb heavy metal ions in water. The resulting PLA@GO microbubble showed a homogeneous spherical structure with a size of 500-1.5 μm, which was suitable for its effective separation from water. The optimal dosage of PLA@GO microbubbles was 10 mg, the pH value of the solution was 5.0, and the adsorption time was 20 minutes which correlates to 75 mg/L of leadions.

Conclusion: The characteristics of the PLA@GO microbubbles showed a strong adsorption capacity, high adsorption efficiency, and a shorter balance time which provided an environment-friendly new material to remove heavy metal ions from water.

Table and Figures | Reference | Related Articles | Metrics
Emerging Applications of Contrast-enhanced Ultrasound in Trauma
Brenda E. Tester, BS, MS, Ji-Bin Liu, MD, John R. Eisenbrey, PhD, George Koenig, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 39-47.   DOI: 10.37015/AUDT.2022.220017
Abstract196)   HTML29)    PDF(pc) (22516KB)(283)       Save

The use of contrast-enhanced ultrasound (CEUS) has expanded over the past decade to include a variety of diagnostic and therapeutic applications. These include urgent clinical situations that require timely diagnosis and subsequent treatment. With the introduction of microbubble ultrasound contrast agents (UCAs), CEUS provides increased sensitivity and specificity over conventional ultrasound. Within the trauma setting, CEUS benefits include point of care imaging and an ability to monitor perfusion in real-time. Additionally, UCAs are non-nephrotoxic, and can be used when contrast enhanced CT is contraindicated. In this review, we discuss recent advancements of CEUS within trauma settings.

Reference | Related Articles | Metrics
Role of Lung Ultrasound in Diagnosing and Differentiating Transient Tachypnea of Newborn and Respiratory Distress Syndrome in Preterm Neonates
Srinivasan S, MD, Neeti Aggarwal, MD, Sushma Makhaik, MD, Anupam Jhobta, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 112-118.   DOI: 10.37015/AUDT.2022.210034
Abstract187)   HTML9)    PDF(pc) (851KB)(335)       Save

Objective: Transient tachypnea of newborn (TTN) and respiratory distress syndrome (RDS) are the most common causes of respiratory distress among preterm neonates. The aim of this study was to evaluate the accuracy of lung ultrasonography (LUS) for diagnosing and differentiating TTN and RDS in preterm neonates.

Methods: This was a prospective single center study. From January 2020 to June 2021 a total of 114 preterm neonates who were admitted to neonatal intensive care unit (NICU) with symptoms of respiratory distress within 6 hours of birth were subjected to clinical examination, laboratory testing, chest x-ray (AP and lateral view’s) and LUS. Their clinical course was closely monitored. On the basis of final diagnosis made on day three of admission they were divided into two groups, 37 diagnosed with TTN and 61 with RDS. Patients diagnosed with other conditions including neonatal pneumonia, meconium aspiration syndrome etc. were excluded from analysis. LUS findings in RDS and TTN were analyzed and compared to each other.

Results: Pulmonary edema manifesting as alveolo-interstitial syndrome, double lung point and less commonly as white out lungs in absence of consolidation had a 100% sensitivity and specificity in diagnosing TTN. A combination of three signs of consolidation with air or fluid bronchograms, white out lungs and absent spared areas has a 100% sensitivity and specificity for diagnosing RDS. Double lung point was seen only in infants suffering from TTN while consolidation with air or fluid bronchograms was only seen in cases of RDS.

Conclusion: Lung ultrasound can accurately diagnose and reliably differentiate TTN and RDS in preterm neonates. Hence LUS can become an initial screening tool in NICU.

Reference | Related Articles | Metrics
Intel® oneAPI Base Toolkit Helps SonoScape Optimize the Performance of Its S-Fetus 4.0 Obstetric Screening Assistant
Intel; Naizhang Feng, Guoyi Zhou
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 238-244.  
Abstract184)   HTML10)    PDF(pc) (823KB)(277)       Save
Table and Figures | Reference | Related Articles | Metrics
Diagnosis And Management of Carotid Atherosclerosis with 3D Duplex Ultrasonography
Muhammad Hasan, MBBCh , RPVI , RVT , RDCS , RDMS
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 245-246.  
Abstract166)   HTML3)    PDF(pc) (348KB)(259)       Save
Reference | Related Articles | Metrics
Automated Cardiac Measurements
Isabella Braun, Matthias Friedrichs, Sean Lucas, Hendrik Wiebel
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 247-248.  
Abstract149)   HTML1)    PDF(pc) (340KB)(212)       Save
Table and Figures | Reference | Related Articles | Metrics
Ultrasonographic Features of Intrathyroidal Thymic Carcinoma: Review and Analysis of 10 Cases
Yanhai Wang, MD, Hua Yang, MD, Hanqing Liu, MD, Xiaoli Luo, MD, Luying Liu, BS, Pingting Zhou, BS
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 58-63.   DOI: 10.37015/AUDT.2022.220013
Abstract147)   HTML20)    PDF(pc) (2979KB)(145)       Save

ObjectiveIntrathyroidal thymic carcinoma (ITTC) is a rare epithelial tumor of the thyroid gland. Since ITTC is rare, its imaging findings have not been well defined. In the present study, we studied the US appearance of ITTC by analyzing ten cases retrospectively.

Methods Patients were identified by searching the surgical pathology records at our hospital. There were three male and seven female patients ranging in age from 40 to 79 years. The ultrasound (US) features were evaluated, and the relevant clinical data were combined with the fine needle aspiration (FNA) results from previous publications.

Results The average length of the nodules was 48 mm. Of all ten nodules, half were located in the right lobe of the thyroid, and half were located in the left lobe, either immediately adjacent to the lower lobe or within the lower part of the thyroid lobe. All nodules manifested with a completely solid composition and heterogeneous hypoechoic echogenicity. Three nodules had striped hyperechogenicity within the nodule. All nodules had irregular margins. Seven had a horizontal shape, and three had a vertical shape. Four nodules manifested with mainly peripheral vascularity, two nodules showed mainly central vascularity, and three had mixed vascularity. The vascularity of one remaining nodule was unknown. Cervical lymph node metastasis was detected in two cases by US examination. According to previous literature, FNA cytology revealed atypical type of thyroid cancer, poorly differentiated carcinoma, or a high-grade malignant thyroid neoplasm without further definitive classification.

ConclusionA large cancer-like nodule located within the lower thyroid in middle-aged people, combined with an atypical type of thyroid cancer after FNA, indicated that ITTC should be considered.

Reference | Related Articles | Metrics
Follicular Thyroid Neoplasmon Conventional and Contrast-enhanced Ultrasound
Xuehong Diao, MD, Lin Chen, MD, Bo Yu, MS, Jiamei Jin, MS, Jia Zhan, MD, Yue Chen, BS
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 48-57.   DOI: 10.37015/AUDT.2022.210026
Abstract146)   HTML10)    PDF(pc) (23436KB)(124)       Save

Objective: The aim of this study was to identify features of follicular thyroid neoplasm by conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) based on morphological and pathological correlations and make diagnostic strategy for predicting malignancy.

Methods: Conventional US and CEUS were performed in 21 follicular thyroid cancers (FTCs) and 35 follicular adenomas (FAs) that were pathologically approved. Sonographic features were retrospectively reviewed, and diagnostic performance were analyzed using pathology as reference standard.

Results: The most useful character in diagnosis of FTC by conventional US was round shape (OR=6.6), followed by absent of halo sign (Odds ratio, OR = 4.79) and calcification (OR = 3.875). Among all CEUS morphological and blow flow findings, incomplete rim enhancement pattern (OR = 19.2) and the presence of perfusion defects (OR = 5.454) were the most effective features to discriminate between FTC and FA. Based on the five discriminatory parameters, a diagnostic criterion was established to assess the risk of FTC. The sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV) and accuracy for predicting malignancy were 81.0 %, 80 %, 70.8 %, 87.5 % and 80.4%, respectively.

Conclusions: CEUS provided additional sonographic features which is helpful for predicting potentially malignancy of follicular thyroid neoplasm.

Reference | Related Articles | Metrics
Current Status, Prospect and Bottleneck of Ultrasound AI Development: A Systemic Review
Siyi Xun, MA, Wei Ke, PhD, Mingfu Jiang, MA, Huachao Chen, BA, Haoming Chen, BA, Chantong Lam, PhD, Ligang Cui, MD, Tao Tan, PhD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (2): 61-72.   DOI: 10.37015/AUDT.2023.230020
Abstract140)   HTML17)    PDF(pc) (11417KB)(218)       Save

In recent years, ultrasound imaging has become an important means of medical diagnosis because of its safety and radiation-free advantages. With the continuous progress of deep learning, Artificial Intelligence (AI) models can process large amounts of ultrasound data quickly and accurately, providing decision support for clinicians in diagnosis. From the perspective of ultrasound image classification, detection and segmentation, this paper systemically introduces the latest progress of AI technology in ultrasound imaging, and summarizes the recent high-level related work. At the same time, we also discuss the development prospect and bottleneck of AI in ultrasound imaging processing, which provides the future research directions for researchers in related fields.

Table and Figures | Reference | Related Articles | Metrics
Cover, Foreword and Content
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 0-0.  
Abstract138)      PDF(pc) (16318KB)(278)       Save
Related Articles | Metrics
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (4): 223-237.  
Abstract137)   HTML4)    PDF(pc) (383KB)(165)       Save

The Annual National Congress of the Chinese Society of Ultrasound in Medicine (CSUM) is one of the most prestigious and influential academic conferences in China, with the largest number of participants. The 22th Annual Meeting of Chinese Society of Ultrasound in Medicine (CSUM 2022) will be held from November 3 to November 6 in Chengdu, Sichuan, China. The scientific program of the meeting received 4,625 proceeding papers which covers the latest developments and trends in basic and clinical ultrasound research, continuing education and promotion of ultrasound-related guidelines and consensus, clinical application of new technologies such as interventional ultrasound, elastography, real-time three-dimensional ultrasound, and contrast-enhanced ultrasound.

The conference will hold a Young English-Presentation Forum to provide a stage for early career doctors to display academic achievement and cultivate the international vision of young physicians. A total of 271 papers were submitted for this forum, including 20 on Ob/Gyn ultrasound, 75 on abdominal ultrasound, 55 on interventional ultrasound, 45 on superficial organs and vascular ultrasound, and 76 on echocardiography. Under the recommendation of the Academic Committee of the General Assembly, the journal of AUDT selected 25 abstracts from the oral presentation group to be published online and in print. Following publication in AUDT, these abstracts can be cited as scientific publications and shared with the international community.

Reference | Related Articles | Metrics
Incidental Ultrasound Findings of a Giant Retroperitoneal Schwannoma: A Case Study
Jiaqi Zhao, MD, Weiqing Li, MD, Xiaolin Ma, MD, Rui Chen, MD, Lin Chen, MD
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 64-67.   DOI: 10.37015/AUDT.2022.210010
Abstract134)   HTML8)    PDF(pc) (23925KB)(91)       Save

Schwannoma in retroperitoneal region is quite rare. In this report, we presented such a rare case of a large size schwannoma in a 23-year-old man admitted with a complaint of mild pain in his right lower abdomen. The abdominal ultrasonography detected a round-shaped heterogeneous hypoechoic mass with a few blood flow signals at the retroperitoneal area inferior to the right kidney. The contrast-enhanced ultrasound demonstrated a well-demarcated hypoechoic mass with minor vascularization. Computed tomography (CT) diagnosed the retroperitoneal mass as a malignant neoplasm. After surgical resection, histopathologic examination revealed that the mass was a benign cellular schwannoma. Besides the rare case of schwannoma in retroperitoneal region, we believe that multimodal sonographic patterns are conducive to the preoperative diagnosis of retroperitoneal neurilemmoma.

Reference | Related Articles | Metrics
Diagnosis of Anomalous Origin of Left Main Coronary Artery from Right Sinus of the Valsalva Based on the “Seagull Sign” in Echocardiography: A Case Study
Yun Zheng, MM, Shiwen Fu, MM, Wei Miao, MM, Shanshan Qu, MM, Junhua Wang, MM, Liping Guo, MM, Xihe Sun, MM
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (2): 68-71.   DOI: 10.37015/AUDT.2022.210032
Abstract119)   HTML2)    PDF(pc) (2735KB)(249)       Save

The anomalous origin of the left main coronary artery from the right sinus of the Valsalva (ALCA) is rare, and varies significantly in congenital heart disease. Patients are usually asymptomatic, and in most cases, coronary abnormalities are discovered by chance at autopsy after coronary angiography or sudden cardiac death. As a routine physical examination procedure, echocardiography is particularly important for the rapid and sensitive diagnosis of ALCA. We report a case of ALCA using echocardiography. “Seagull sign” is a direct ALCA sign manifesting on the short axis section of the artery with two vessels coming from the right coronary sinus. Based on this case, we propose this specific ultrasound sign as a way to improve the diagnostic rate.

Reference | Related Articles | Metrics
Cover, Foreword and Content
Advanced Ultrasound in Diagnosis and Therapy    2022, 6 (3): 0-0.  
Abstract118)      PDF(pc) (2952KB)(165)       Save
Related Articles | Metrics
Application and Progress of Ultrasound Technology in Atherosclerosis
Qiaoer Gong, BS, Nianyu Xue, MS
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (1): 8-15.   DOI: 10.37015/AUDT.2023.220030
Abstract106)   HTML16)    PDF(pc) (843KB)(126)       Save

Atherosclerosis (AS) is the main pathophysiological process behind CVD. Cardiovascular diseases caused by AS (such as stroke, coronary heart disease, etc.) are characterized by a high prevalence, high disability rate and high mortality, which greatly increase the burden on families and society. Thus, it is important to find AS as early as possible. When atherosclerosis occurs, the earliest sign of its structural and functional changes is arterial stiffness, and endothelial dysfunction is the key link. Arteriosclerosis is caused by the imbalance between collagen and elastin in the arteries. Elastin fibers gradually decrease, and stiffer collagen fibers increase, making the vessels less elastic. Endothelial dysfunction also affects the regulatory function of arterial vascular tension, and accelerates the remodeling of the vascular wall, to make blood vessels more rigid. Quantitative measurement of arterial stiffness and carotid intima-media thickness (CIMT) is an important tool for early detection of vascular lesions. At present, ultrasound technology including echo tracking (ET), wave intensity (WI), real-time shear wave elastography (SWE), ultrafast pulse wave velocity (ufPWV), shear wave dispersion (SWD), cardio-ankle vascular index (CAVI), arterial velocity pulse index and arterial pressure volume index (AVI and API) has the advantages of being noninvasive, real-time, economical and reproducible in the assessment of atherosclerosis, and is widely used in the early diagnosis of AS. Most importantly, the change in arterial hardness detected by traditional ultrasound technology precedes the change in intima-media thickness, suggesting that ultrasonic elasticity monitoring may be a more sensitive method of predicting AS and can find and prevent cardiovascular diseases earlier.

Reference | Related Articles | Metrics
Sentinel Lymph Node Identification Using Contrast Lymphosonography: A Systematic Review
Priscilla Machado, MD, Ji-Bin Liu, MD, Flemming Forsberg, PhD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (1): 1-7.   DOI: 10.37015/AUDT.2023.230001
Abstract102)   HTML19)    PDF(pc) (861KB)(109)       Save

The sentinel lymph node (SLN) concept hypothesizes that metastatic cancer cells will spread through the lymphatic system to the SLN being the first one in the lymphatic chain to receive the metastatic cells, indicating that if the SLN is free of cancer cells the rest of the lymphatic chain is also without metastatic disease. Diagnostic ultrasound imaging (US) has been used to evaluate lymph nodes (LN) to determine level of suspicion and to guide LN biopsies. However, conventional US cannot be used for lymphatic mapping, which requires administration of a tracer. This has been changed with the use of contrast-enhanced US (CEUS) to detect lymphatic channels and SLNs after subcutaneous injections of microbubble-based US contrast agents (UCAs). The aim of this review is to examine the clinical evidence on the role of subcutaneous injection of UCA, known as lymphosonography, to be used as preoperative identification of SLNs in patients with breast and other cancers.

Table and Figures | Reference | Related Articles | Metrics
Intelligent Ultrasonic Diagnosis and Clinical Application: Technical Development and Prospectives
Rendong Chen, PhD, Xiaoqian Wang, BS, Ping Liang, MD, Xiaoping Ouyang, PhD, Dexing Kong, PhD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (2): 73-81.   DOI: 10.37015/AUDT.2023.230019
Abstract98)   HTML18)    PDF(pc) (11300KB)(112)       Save

Ultrasound intelligent diagnosis is an emerging technology that combines artificial intelligence (AI) and medical ultrasonography. It has gained significant attention in recent years due to its potential to improve the accuracy and efficiency of medical diagnosis. The core elements of ultrasound artificial intelligence are the construction of data and algorithm models. Therefore, developing autonomous and controllable models, algorithms, and data platforms is extremely important. In this paper, we provide a comprehensive review of the current state-of-the-art in ultrasound intelligent diagnosis including the aspects of the construction of ultrasonic database, deep learning techniques in ultrasound intelligent diagnosis, and the clinical application of ultrasound-AI products. With continued advancements in AI and ultrasound imaging technology, we believe ultrasound intelligent diagnosis will be a valuable tool in the hands of healthcare professionals, providing them with more accurate and efficient diagnoses and treatment plans in the coming years.

Table and Figures | Reference | Related Articles | Metrics
Predicting Malignancy in Sonographic Features of Thyroid Nodules Using Convolutional Neural Networks ResNet50 Model
Jingfang Dong, MD, Jianyun Wang, MD, Xiangzhu Wang, MD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (1): 16-22.   DOI: 10.37015/AUDT.2023.220023
Abstract89)   HTML13)    PDF(pc) (1052KB)(107)       Save

Objective To predict sonographic features of malignancy in thyroid nodules by using convolutional neural networks (CNNs) ResNet50 model.

Methods A cohort of 461 patients having sonographic thyroid nodules with histology diagnosis were randomly split into training set (70%), validation set (15%) and testing set (15%). Labeled sonographic patterns of thyroid nodules were used to train CNNs ResNet50 in training set, where algorithm pipelines were used to explicitly delineate structures of interest using segmentation algorithms to measure predefined characteristics of these structures as to be predictive and to use these features to train models that predict the malignancy in thyroid nodules. The prognostic accuracy of ResNet50 model was evaluated on validation set and compared with the individual sonographic specialists in testing set. Accuracy, sensitivity, specificity, and efficiency of ResNet50 model was measured using receiver operating characteristic (ROC) curve.

Results Measurements showed the evaluation indexes of ResNet50 model were as follows: accuracy: 94.39%, sensitivity: 92.45%, specificity: 96.30%, efficiency: 96.08%, F1 value: 94.23%, and AUC: 93.40%. The prognostic accuracy and other indexes of ResNet50 model was not subordinate compared to sonographic specialists (P < 0.05).

Conclusion These results highlight the emerging role of deep learning techniques including CNNs in precision medicine and suggest an expanding utility for computational analysis of sonographic images in the future practice. This study showed a computational approach can be used for learning sonographic features of thyroid nodules using ResNet50 model to combine the power of adaptive machine learning and algorithms with traditional sonographic assessment.

Table and Figures | Reference | Related Articles | Metrics
Application of Ultrasound-guided Stellate Ganglion Block in Treatment of Allergic Rhinitis
Chunyao Liu, BS, Huiwen Li, MS, Yajiang Zhang, MS, Ji Liu, BS, Jingru Yang, MS, Wei Li, MS, Jin Gao, BS, Rong Wu, MD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (1): 23-27.   DOI: 10.37015/AUDT.2023.220008
Abstract88)   HTML4)    PDF(pc) (914KB)(99)       Save

Objectives To assess the clinical efficacy and safety of ultrasound-guided stellate ganglion block in the treatment of allergic rhinitis.

Methods Sixty patients with allergic rhinitis were selected as study subjects and were treated with stellate ganglion blocking. We observed the appearance and time of the patient's Horner syndrome, and compared the patient's clinical symptom scores before and after one month treatment, and calculated the clinical efficacy and overall effective rate.

Results After ultrasound-guided stellate ganglion blocking treatment, 97% of patients occurred Horner syndrome within 2 minutes. The scores of sneezing, runny nose, nasal itching, and nasal congestion significantly reduced at one month after treatment compared with those before treatment, in which there was statistically significant difference (P<0.05). The clinical efficacy rate also reached 96.7% after procedures. No serious complications occurred in this study.

Conclusions Ultrasound-guided stellate ganglion block can significantly improve the clinical symptoms and the life quality for patients with allergic rhinitis, and it is worthy of extensive clinical application.

Table and Figures | Reference | Related Articles | Metrics
ChatGPT Related Technology and Its Applications in the Medical Field
Tairui Zhang, BS, Linxue Qian, MD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (2): 158-171.   DOI: 10.37015/AUDT.2023.230028
Abstract88)   HTML10)    PDF(pc) (12139KB)(62)       Save

ChatGPT is attracting widespread attention from all walks of life with its excellent multi-round dialogue ability and strong user intent understanding ability, triggering a new wave of artificial intelligence. From the perspective of technical analysis, this article sorts out the various related technologies used in the GPT (Generative Pre-training Transformer) series models as well as large-scale multimodal models, which are more powerful and perform better in multiple downstream tasks. Meanwhile, we guide users to use LLM (Large Language Model) along with GPT more scientifically to maximize their potential. Finally, we analyze the application prospect of the GPT as well as the large-scale multimodal models in the medical field, and the problems are discussed from the perspectives of the risks and limitations of large-scale models applied into the medical field.

Table and Figures | Reference | Related Articles | Metrics
Deep Learning on Ultrasound Imaging for Breast Cancer Diagnosis and Treatment: Current Applications and Future Perspectives
Changyan Wang, BS, Haobo Chen, MS, Jieyi Liu, BS, Changchun Li, BS, Weiwei Jiao, BS, Qihui Guo, BS, Qi Zhang, PhD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (2): 91-113.   DOI: 10.37015/AUDT.2023.230012
Abstract78)   HTML3)    PDF(pc) (11701KB)(77)       Save

Ultrasound is a commonly used imaging modality for breast cancer diagnosis and prognosis but suffers from false positives, false negatives and interobserver variability. Deep learning (DL), a subset of artificial intelligence, has the potential to improve the efficiency and accuracy of breast ultrasound. This article provides a comprehensive overview of DL applications for breast cancer diagnosis and treatment in ultrasound, including methodological descriptions of various DL models, and clinical applications on noise reduction, lesion localization, risk assessment, diagnosis, response evaluation and outcome prediction. Furthermore, the review highlights the importance of interpretability and small sample size learning of DL-based systems in clinical practice; specific recommendations for further expanding the clinical impact of DL-based systems are also provided.

Table and Figures | Reference | Related Articles | Metrics
Artificial Intelligence in Prenatal Ultrasound: Clinical Application and Prospect
Wenjia Guo, MM, Shengli Li, MM, Xing Yu, MD, Huaxuan Wen, BM, Ying Yuan, MM, Xia Yang, MM
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (2): 82-90.   DOI: 10.37015/AUDT.2023.230024
Abstract71)   HTML7)    PDF(pc) (11800KB)(86)       Save

Since the 1990s, researchers have been seeking approaches for applying artificial intelligence (AI) to prenatal ultrasound. With the breakthrough of cloud computing technology and the development of deep learning technology, AI in prenatal ultrasound has already entered the clinical application stage in recent years. How does AI combine with clinical prenatal ultrasound? Is the clinical application of AI in prenatal ultrasound effective? What can we expect from AI in prenatal ultrasound? This review introduces the latest developments in this field and explores the challenges and opportunities brought by AI to prenatal ultrasound.

Table and Figures | Reference | Related Articles | Metrics
Multimodal Vascular Ultrasound Findings in A Young Female with Internal Carotid Artery Dissection
Zehui Fu, MD, Chuxue Sun, MD, Haixia Zhou, MD, Xiaowen Lv, MD, Siqi Wang, MD, Hui Chen, MD
Advanced Ultrasound in Diagnosis and Therapy    2023, 7 (1): 28-31.   DOI: 10.37015/AUDT.2023.210035
Abstract69)   HTML7)    PDF(pc) (909KB)(113)       Save

Internal carotid artery dissection (ICAD) is the result of a tear at the intimal layer of the internal carotid artery, which is a common cause of stroke in young and middle age patients. We present multimodal vascular ultrasound findings (include color Doppler flow, power Doppler flow, advanced dynamic flow, superb microvascular and contrast enhanced ultrasound imaging) of a 30-year-old female with ICAD and thrombus in false lumen. To our best knowledge, this is the first report that several superior vascular ultrasound imaging techniques have been used to evaluate ICAD.

Table and Figures | Reference | Related Articles | Metrics

Open Access, Peer-reviewed

ISSN 2576-2516 (Online)

ISSN 2576-2508 (Print)

Indexed/Tracked/Covered By:

Top 10 DownloadsMore
Top 10 ClicksMore