Advanced Ultrasound in Diagnosis and Therapy ›› 2018, Vol. 2 ›› Issue (3): 173-177.doi: 10.37015/AUDT.2018.180820

• Original Research • Previous Articles     Next Articles

The Correlation between Traditional Ultrasound Features and the Expression of Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor-2, and Ki-67 in Breast Carcinoma

Ping Wang, MMa*(), Junfan Lib, Wensheng Yue, MMa, Wenyan Li, MMa, Yuqun Luo, MMa   

  1. a Department of Ultrasound, the Affiliated Hospital of North Sichuan Medical College, Nanchong, China
    b Department of Radiology, the Beibei Chinese Medicine Hospital, Beibei, China
  • Received:2018-10-23 Online:2018-12-29 Published:2018-12-29
  • Contact: Ping Wang, MM,


Objective: To evaluate the correlation between traditional ultrasound and the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (Her-2), and Ki-67 expression in breast carcinoma.

Methods: A retrospective analysis of 400 cases of breast cancer, which were confirmed by pathology. The expression of postoperative specimens by immune-histochemical staining was used to evaluate the immune molecules ER, PR, Her-2, and Ki-67. The correlation between the ultrasound findings (size, boundary, sand calcification, and blood flow grade), as well as the expression of ER, PR, Her-2, and Ki-67 were analyzed.

Results: Of the 400 cases, there were no correlations between the boundary, the classification, or the blood flow of the tumor with the expression of ER, PR, Her-2, and Ki-67. The size of tumor was correlated with Her-2 and Ki-67. The tumor is the bigger, and the expression of Her-2 and Ki-67 is higher.

Conclusion: There is a correlation between tumor size and expression of Her-2 and Ki-67 in breast cancer. The combination of them was important for the treatment and prognosis of breast cancer.

Key words: Traditional ultrasound; Breast cancer; ER; PR; Her-2; Ki-67