Advanced Ultrasound in Diagnosis and Therapy ›› 2018, Vol. 2 ›› Issue (2): 71-81.doi: 10.37015/AUDT.2018.180803

• Review Article • Previous Articles     Next Articles

Ultrasonic Thermal Strain Imaging for Noninvasive Temperature Estimation in Tissue

Wenlong Zenga, Christopher J Kruegera,b, Zhifei Dai, PhDa,*()   

  1. a Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
    b Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
  • Received:2018-07-18 Online:2018-08-18 Published:2018-08-19
  • Contact: Zhifei Dai, PhD,


By virtue of advantages including no exposure to radiation and low toxicity and side effects, hyperthermia has been increasingly applied in treating cancer and other diseases. However, the challenge of continuous temperature monitoring during hyperthermia limits its further application. Currently, temperature monitoring in the clinic is primarily carried out using invasive thermometry, which is hampered by incomplete detection and pain. To overcome the obvious limitations of invasive thermometry, a variety of noninvasive thermometry methods with suitable accuracy have been explored. Among these, ultrasonic thermal strain imaging (UTSI), which exploits the temperature dependence of ultrasonic echo time shift to form thermal strain images, shows significant potential. It not only possesses the merits of ultrasonography but also displays different tissue characteristics (thermal properties of tissue and sound velocity) from other ultrasound imaging methods, so it has been investigated extensively over the past few years. This paper reviews recent advances in UTSI for noninvasive thermometry and discusses its main limitations, hoping to show the strong clinical application potential of UTSI from solid basic theory and practical research results.

Key words: Ultrasonic thermal strain imaging; Hyperthermia; Noninvasive thermometry; Motion compensation